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1 Polish Journal of Applied Chemistry

1 2009

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Functional poly (ester-anhydride) microspheres

Jaszcz K., Łukaszczyk J.

Polish Journal of Applied Chemistry

2009

Vol. 53, nr 1

1-7

Functional microspheres were prepared from poIy(ester-anhydride)s with allyl pendant groups, using a solvent removal technique. The poly(ester-anhydride)s were obtained by polycondensation of sebacic acid (SBA) and oligo(3-allyloxy-l,2-propylene succinate) terminated with carboxyl groups (OSAGE). The SBA and OSAGE content influenced the characteristics of poly(ester-anhydride)s and microspheres. The poly(ester-anhydride)s differed with their solubility and thermal properties as well as their degradation rate and mode. Stable microspheres with size in the range of 15-60 nm were obtained from poly(ester-anhydride)s containing more than 60% SBA. The microspheres obtained from po!y(ester-anhydride)s containing 60% SBA had tendency to aggregation. Microspheres were not obtained when content of SBA in poly(ester-anhydride)s was lower than 60%. All particles were spherical, however those prepared from polymers containing 90 or 80% SBA possessed smoother surfaces when compared to those prepared from poly(ester-anhydride)s containing 70 or 60% SBA. Ability of poIy(ester-anhydride)s to be formulated as microspheres would enable their eventual use in drug delivery systems.