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R&D of novel medicinal materials for curing cancer: sugar modified Gd-DTPA MRI contrast agents and phospha sugar anti-cancer agents

Yamashita Y., Yamashita M., Fujie M., Suyama K. A. T., Ito S., Reddy V. K., Yamada M., Ogawa K., Ozaki N., Nakamura S., Aoki T., Yu G., Aoshima K., Kato T., Kamikage N., Kiyofuji K., Takehara Y., Sakahara H., Takayanagi H., Oshikawa T., Laurent S., Burtea C., Van der Elst L., Muller R. N.

Journal of Automation Mobile Robotics and Intelligent Systems

2009

Vol. 3, No. 4

80-83

Novel Sugar Dendritic Gd-DTPA Complexes for MRI Contrast Agents were prepared and evaluated by in vitro and in vivo methods. The sugar dendritic MRI contrast agents have a good blood vesse pool character, and draw blood vessels and liver cancer remarkably clearer than the clinically using Gd-DTPA. Phospha sugar derivatives or phosphorus heterocyclic derivatives provided by functional groups such as epoxide, bromide, etc., were prepared and evaluated by MTT in vitro method. These phospha sugar derivatives showed excellent activities against leukemia cells as well as solid cancer cells in fashions of (i) higher activity, (ii) wider spectra, (iii) higher selectivity and specificity distingushing healthy and cancer cells, etc., compared with the molecular targeting chemotheraputic anti-cancer agent, Gleevec.