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1 Journal of Medical Informatics & Technologies

1 2004

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Limitations of DSC-MRI for quantitative brain perfusion

Rumiński J., Bobek-Billewicz B.

Journal of Medical Informatics & Technologies

2004

Vol. 8

MM49--58

Synthesis of quantitative parametric images in DSC-MRI is presented. Critical review of major limitations of the DSC-MRI method is discussed. It includes investigation of measurement procedures/conditions as well as parametric image synthesis methodology. Simulations, as well as phantom studies were used to verify theoretical limitations of the DSC-MRI. Especially, estimation of the contrast (Gd-DTPA) concentration by EPI measurements, the role of a phantom and its pipes orientation, influence of a bolus dispersion, bolus arrival time, and other signal parameters on an image quality. As a conclusion testing software package is proposed.