The paper presents proposal for image data unit description using a half-byte format. It was implemented for medical images description. The introduced definitions express pixel values using differences between pixels and the introduced base value. This way the image recorded at half-byte format can be simply compressed by an appropriate compression, methods more effectively. The half-byte format is suitable for so called "natural" images with textures that are usually compressed with not satisfying results. For the given method illustration some example results were introduced.
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