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Stimulation of osteogenezis to fight with osteoporozis

Pawlikowski M.

Auxiliary Sciences in Archaeology, Preservation of Relics and Environmental Engineering

2018

nr 24

1--5

Osteoporosis is not only process of destruction of bones. Elements removed from bones may migrate to soft tissue and crystalize there leading to many health troubles and often to death. Phenomenon of osteogenesis were described as biological- mineralogical reactions. Discussion concerning osteogenesis is presented in frames of bone creation and destruction. One can conclude the natural processes of none formation is possible use to fight with osteoporosis.

Osteoporoza nie jest wyłącznie procesem niszczenia kości. Pierwiastki wyprowadzane z kości mogą migrować do tkanek miękkich i tu krystalizować powodując wiele problemów zdrowotnych a nawet śmierć. Przedstawiono proces osteogenezy(kościotworzenia) jako zjawisko biologiczno-mineralogiczne. Dyskusje dotyczącą osteogenezy przedstawiono jako tworzenie i niszczenie kości. Stwierdzono, że naturalne procesy formowania kości można wykorzystać do walki z osteoporozą.

Tissue engineering of bone: the role of osteoblasts in osteogenesis and peri-implant bone healing

Wróbel E., Witkowska-Zimny M.

Engineering of Biomaterials

2013

Vol. 16, no. 119

2--7

Osteoblasts are cells of mesenchymal origin, which rebuild resorbed bone by synthesizing bone matrix proteins and by inducing bone matrix mineralization. Osteoblasts play a crucial role in creating and maintenance of healthy bone architecture, bone repair, and peri-implant bone healing (osseointegration). These bone-forming cells are also involved in regulation of osteoclasts function, and hence bone resorption in osteoclastogenesis process. We have presented our own studies on the subsequent stages of differentiation of Human Bone-Derived Cells (HBDCs) that could be a good candidate as an autogenous source for reconstruction and rebuilding of own patient's bone using tissue engineering methods. In this review we discussed the biology of osteoblasts, compared with the HBDCs cultures, under the influence of growth factors (FGF-2, TGF-ß, IGF, PDGF) and hormones (PTH, 1,25-dihydroxyvitamin D3, leptin). Our review is also focused on the participation of intercellular adhesion proteins (cadherins, claudins, connexin, 'OsteoMacs'), transcription factors (Cbfal, Msx-2, Osx, ATF4), and others molecules (RANKL, OPG, BMP2, lactofferin, PPARY) in modulating osteoblasts functions on the basis of current reports, throwing new light on the involvement of osteoblasts during osteogenesis and peri-implant bone healing.

Distraction osteogenesis and fracture healing : differences and similarities

Kuryszko J., Kuropka P., Jedrzejowska I.

Acta of Bioengineering and Biomechanics

2000

Vol. 2, nr 2

83-88

In experimental research dealing with repair osteogenesis different aspects of its course are stressed. The osteotomy type influences osteoinduction and development of blood vessels, whereas biomechanical features of bone tissue are obtained by proper stabilisation of newly formed callus. Different directions of callus evolution create their final morphology. In this paper, similarities and differences in regenerate and callus morphology are compared in detail.