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Purpose: The science that involves nano-sized particles have been shown to have a huge impact on a variety of research fields, such as electronics, medicine, engineering, robotics and technology. The involvement of biological agents in nanoscience helped in the origin of bionanotechnology, which is deeply rooted in therapeutic and medical applications. This review provides an initiative to understand the combination of biological molecules and nanoparticles in delivering a great impression in the world of therapeutics. Design/methodology/approach: Conjugation of nanoparticles with the biological molecules makes them more friendly for the living system by increasing biocompatibility and reducing toxicity. Findings: Growing research in this area has revealed the identification and characterization of numerous biological agents of nano-sized that can serve as better carrier systems. They are exploited in the development of advanced nanoparticle-based targeted drug delivery systems. In general, either the combined form or the one in the derived form of nanoparticles from different biological organisms provides a valuable understanding of their specifications and importance in different therapeutic aspects. Research limitations/implications: The combined form of biological molecules and nanoparticles is not yet well understood, and this might provide a baseline for prospects. Originality/value: This review provides an understanding of biologically synthesized and conjugated nanoparticles and their potential as therapeutic norms and highlights their applications, especially in the clinical field.
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