Slope stability of open pit mines has been a hot issue of economic and safety concern. In order to reduce the accidental casualties caused by slope instability, targeted reinforcement solutions should be proposed for them. In this paper, GeoStudio and FLAC3D software were used to model the slope an open pit mine. The safety factors of the slope under natural, rainfall and seismic conditions are analyzed in turn. Additionally, the safety factors derived from different algorithms are compared to mutually verify the reliability of the slope stability analysis. Two sets of reinforcement design solutions – anchor rod and anti-slip pile – are proposed. Then, the two solutions are optimized so that the safety factors of the slope under three conditions reach 1.3, 1.2 and 1.1, respectively, and the optimal solution is selected from the two solutions by combining the economic benefits. The results show that the optimized anchor and anti-slide pile reinforcement solutions result in the safety factors of the slope under different conditions, reaching 1.441, 1.258, and 1.324 and 1.4, 1.238, and 1.23, respectively. The anti-slide pile reinforcement solution is more economical than the anchor reinforcement solution, so it is recommended that the anti-slide pile reinforcement solution should be chosen as the final solution.
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