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1 Journal of Medical Informatics & Technologies

1 2010

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Cortical pattern detection for the developing brain: a 3D vertex labeling and skeletonization approach

Clouchoux C., Kudelski D., Bouyssi-Kobar M., Viseur S., du Plessis A., Evans A., Mari J.-L., Limperopoulos C.

Journal of Medical Informatics & Technologies

2010

Vol. 16

161--166

Normal brain development is associated with expansion and folding of the cerebral cortex in a normal sequence of gyral–sulcal formation. We propose a global approach for measuring the cortical folding pattern of the developing brain. Our method measures geometric features directly on the cortical surface mesh, based on vertex labeling and skeletonization. The resulting extraction provides an accurate representation of global cortical organization. We applied this method to 17 young infants in order to characterize the evolution of cortical organization in the developing brain.