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Synthesis, Characterization, in-vitro Biocidal and Nuclease Activity of Cu(II), Fe(II) and Fe(III) Complexes

Pansuriya P. B., Chhasatia M. R., Patel S. H., Patel M. N.

Polish Journal of Chemistry

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2008

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Vol. 82, nr 8

1527--1539

EN

Complexes of Cu(II), Fe(II), and Fe(III) have been synthesized by reaction of their metal salts with bis(4-hydroxy-2oxo-2H-chromen-3-yl)-methane or bis(4-hydroxy-2oxo-2Hchromen- 3-yl)-thiophene-2yl-methane or bis(4-hydroxy-2oxo-2H-chromen-3-yl)-pyri -din-3yl-methane in molarratio 1:2. They have been characterized using 1H-NMR, 13C-NMR, IR spectra, electronic spectra, magnetic measurements and elemental analyses and screened for their in-vitro antimicrobial activity against Bacillus cereus, Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Salmonella typhi, and Serratia marcescens. The metal complexes exhibit moderate antimicrobial activity compared to parental compounds and standard drugs. In-vi tro nuclease activity has been determined using agarose gel electrophoresis. The synthesized compounds show effective nuclease activity.

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Studies on the Interaction of Transition Metal Complexes of the Schiff Base Derived from Anthranilic Acid and Acetoacetanilide with DNA

Raman N., Rajasekaran K.

Polish Journal of Chemistry

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2007

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Vol. 81, nr 2

149-159

EN

Four neutral complexes of Cu(II), Ni(II), Co(II) and Zn(II) have been prepared with a new tridentate Schiff base (HL) derived from anthranilic acid and acetoacetanilide. The analytical data show that themetal to ligand ratio is 1:2. The structural features have been determined from IR, UV-Vis, 1H-NMR, ESR and mass spectral data. All the complexes exhibit octahedral geometry around the central metal ion. Their low electrical conductance values support their neutral nature. The magnetic moment data provide evidence for the monomeric nature of the complexes. Absorption experiments have been carried out on the interaction of the complexes with calf thymus DNA (CT-DNA). The results suggest that all the complexes can bind to CT-DNA by intercalation between chromophore and DNAbase pairs. An electrochemical study of the copper complex reveals that it prefers to bind to DNA in the Cu(II) rather than the Cu(I) oxidation state. The nucleolytic cleavage activity of all the complexes was examined on CT-DNA by using a gel electrophoresis experiment in the presence and absence of oxidant, H2O2. In the absence of the oxidant, a less discernible DNAcleavage was observed, whereas in the presence of the oxidant, all complexes showed enhanced nuclease activity.

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Studies on DNA Cleavage and Antimicrobial Screening of Transition Metal(II) Complexes Derived from Tetradentate Schiff Base

Raman N., Dhaveethu Raja J., Sakthivel A.

Polish Journal of Chemistry

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2007

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Vol. 81, nr 12

2059-2067

EN

A new series of transition metal complexes of Cu(II), Ni(II), Co(II), Mn(II), Zn(II), VO(IV), Hg(II) and Cd(II) have been synthesized from the Schiff base (H2L) derived from 4-aminoantipyrine, 3-hydroxy-4-nitrobenzaldehyde and 2-aminophenol. The structural features have been arrived from their elemental analyses, magnetic susceptibility, molar conductance, mass, IR, UV-Vis, 1H NMR and ESR spectral studies. The data show that the complexes have composition of ML type. The UV-Vis, magnetic susceptibility and ESR spectral data of the complexes suggest a square planar geometry around the central metal ion except VO(IV) complex which has square-pyramidal geometry. The redox behavior of copper and vanadyl complexes has been studied by cyclic voltammetry. The minimum inhibitory concentration (MIC) values of the in vestigated compounds indicate that the complexes have higher antimicrobial activity than the free ligand. The nuclease activity of the above metal complexes shows that only copper and nickel complexes cleave DNA through redox chemistry.