Synthesis of new conjugates of muramyl dipeptide (MDP) and nor-muramyl dipeptide (nor-MDP) with retro-tuftsin derivatives is presented. The corresponding protected retro-tuftsin derivatives were also synthesized. The synthesis of a greater number of conjugates will enable structure-activity relation ship studies.
The synthesis of retro-tuftsin analogue of sequence Arg-Pro-Lys-ThrOMe (Scheme 1) and it's conjugates containing MDP (muramyl dipeptide) or nor-MDP (nor-muramyl dipeptide) (Scheme 2) are described.
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