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Modal analysis of physiological model of avian embryos – model parameter estimation. Part II

Iwaniec J., Iwaniec M., Pawlak K.

Vibrations in Physical Systems

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2008

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Vol. 23

171--176

EN

The research carried out by authors aimed at inventing the sensitive non-invasive method for ethical investigation into the influence of chemical substances and physical factors on the growth of organisms in the prenatal phase. The knowledge of effects of chemical substances on the course of embryogenesis provides the possibility of testing new medicines and assessing the teratogenous influence of chemical substances already present in the natural environment on alive organisms. The results of the research are presented in the form of the series of two papers under the same title. The first paper, denoted as the part I, concerns the invented noninvasive method dedicated for measurements of low-amplitude vibrations induced by the work of cardiac muscles. The current paper (part II) is dedicated to vibration analysis of measured ballistocardiograps carried out by means of the classical LSCE modal analysis method. Due to the rapid increase in the cardiac muscle mass, the parameters of the biomechanical model of developing avian embryo are nonlinear. Nevertheless in a single measurement session the changes in the object parameters are negligible, which enables application of the classical modal analysis methods.

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Modal analysis of physiological model of avian embryos - identification experiment. Part I

Iwaniec J., Iwaniec M., Pawlak K.

Vibrations in Physical Systems

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2008

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Vol. 23

165--168

EN

Avian embryos are commonly used as ethically acceptable physiological models for research into prenatal live. Although easily available, avian embryos are difficult objects for investigation. The main difficulties result from the presence of shell separating the embryo from environmental influences and, what is more important, from the presence and interference of many biomechanical, chemical, electrical and other phenomena. The tiny changes in the object parameters of different nature are hardly measurable by means of the indirect methods. Investigation into the embryo prenatal life requires application of the non-invasive methods, which complicates the measurements. Taking into account the fact that as early as in the second day of incubation the avian embryo hart begins to work being by itself at the beginning of mutual conversions, it is easy to become conscious of the scale of the measurements and resulting identification problems. In the process of forming and growth, the heart of avian embryo undergoes constant biomechanical modifications. This aspects of embryogenesis are correlated to electrical and hydro-dynamical activity. Only mechanical vibrations and acoustical effects can be analysed on the basis of the indirect non-invasive measurements. The research carried out by authors is presented in the series of two papers. The current paper (part I) concerns the innovative noninvasive method dedicated for measurements of low-amplitude vibrations induced by the work of cardiac muscles while in the second paper (part II) there is presented vibration analysis carried out by means of the classical LSCE modal analysis method. Although the biomechanical model of developing heart is characterized by significant nonlinearity of observed parameters resulting from rapid increase in the cardiac muscle mass, during a given measurement session the changes in the object parameters are negligible and the assumptions of modal analysis are valid. The changes in the proportions and organ masses as well as in time histories and values of forces generated by beating heart are the source of changes not only in the estimated modal model parameters but also in the model order. Some natural frequencies and corresponding mode shapes evolve and change their values, decay or appear. This variability can be observed in the longer time scale (e.g. days). In a single identification experiment lasting up to tens of minutes per day, after elimination of disturbances, the measured vibroacoustical signal can be treated as quasi stationary. Modal model parameters and the model order were determined for each separate measurement session lasting 10 to 40 minutes. Parameter values estimated for the consecutive measurement sessions made it possible to track the changes in modal model in the consecutive days of incubation.

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Metody nieinwazyjnego pomiaru prenatalnego kardiogramu ptasich embrionów

Iwaniec J.

Diagnostyka

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2004

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Vol. 30, T. 1

203--206

PL

Celem pracy było opracowanie całkowicie nieinwazyjnej i bezpiecznej metody diagnostyki czynności serca embrionów ptasich. Zarodki te wykorzystywane są w fizjologii jako czuły detektor i model do badania wpływu czynników fizycznych oraz substancji chemicznych na prenatalne procesy życiowe. Przedstawione metody nieinwazyjnego pomiaru kardiogramu ptasich embrionów oparte są o proste idee i zasady pomiarowe. Pomimo użycia niezbyt drogiego sprzętu metody umożliwiają pomiar już po kilku dniach życia embrionu.

EN

The paper concerns non-invasive and safe method of bird embryo heart action diagnostics. Such embryos are used in physiology as a sensitive detector and a model for testing the influence of physical factors and chemical substances on prenatal life processes. Presented methods of non-invasive measurement of bird embryos cardiograms are based on simple ideas and measurement principles. In spite of the fact that the used equipment is inexpensive, the methods make it possible to carry out the measurements after a few days of embryo life.