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Cyclodextrine vs D-glucose in the solutions of the derivative of 1,4-DHP

Kaczmarek-Klinowska Milena, Hornowski Tomasz

Vibrations in Physical Systems

2019

Vol. 30, nr 1

art. no. 2019110

Hydrophilic and hydrophobic cyclodextrins (CDs) have found a lot of applications in medicine pharmacology, food processing and cosmetology. They can function as a drug carrier material and parent host molecules, increasing drug biocompatibility, optimizing the efficiency of drug activity, and controlling drug release at the desired level. The effectiveness of CD complexation depends on many factors such as the type and the size of both the CD molecule itself and the guest molecule, pH of the solution, and temperature. In aqueous solution of glucose the aggregation of molecules can occur leading to the formation of CD-like structures. In the paper the possibility of the formation of the inclusion complexes of CD and glucose with Nimodipine was investigated with the aid of ultrasonic spectroscopy. By comparing the efficiency of industrial saccharides and glucose in the formation of the inclusion complexes the cost effectiveness of the use of glucose as a substitute for CD can be determined.

Differentiating analysis of some 1,4-dihydropyridine derivatives

Marciniec B., Brzeska A.

Chemia Analityczna

1999

Vol. 44, No. 5

849-855

The conditions for the differential analysis of five derivatives of l ,4-dihydropyridine : nifedipine, nitrendipine, nisoldipine, nimodipine, and nicardipine were deve]oped by the thin-layer chromatography, differentiaI scanning calorimetry, UV and IR spectrophotometry methods.Also the appropriate thermal, chromatographic and spectro-photometric parameters were established.

Opracowano warunki i wyznaczono parametry termiczne, chromatograficzne i spektrofotometryczne umożliwiające analizę różnicującą pięciu pochodnych 1 ,4-dihydropirydyny: nifedypiny, nitrendypiny, nisoldypiny, nimodypiny i nikardypiny metodami TLC, DSC oraz spektrometrii UV i IR.