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1
Content available remote Classification of Alzheimer's disease patients using metrics of oculo-motors
EN
Ocular information was observed during a set of dementia tests involving participants with two diagnostic levels of illness, such as having Alzheimer's Disease (AD), a mild level of cognitive impairment (MCI) patients, and a control group. The number of participants was 26. Features of changes in pupil size and in the central position of both eyes were compared between three levels. There are significant differences in some of the metrics between the levels in the earlier test sessions. The possibility of classification was confirmed using the extracted features, and the contributions of some features were examined.
EN
It is commonly accepted that the various parts of the human brain interact as a network at macroscopic, mesoscopic and microscopic level. Recently, different network models have been proposed to mime the brain behavior both at resting state and during tasks: Our study concerns one of those model that consider both the physical and functional connectivity as well as topological metrics of the brain networks. We provide evidence of the soundness of the model by means of a synthetic dataset based on the existing literature concerning the active cerebral areas at the resting state. Furthermore, we consider Ruzicka similarity measure in order to stress the predictive capability of the model and provide a thresholding criterium. Some network statistics are finally provided.
3
Content available remote Deep brain recordings
EN
Depth recordings from human subcortical structures have improved our knowledge of human brain circuitries and provided better understanding of the effects and mechanism of action of deep brain stimulation. Two types of signals can be recorded: single unit spikes and local field potentials (LFP). The basal ganglia (BG) are particularly well suited for deep brain recordings and here we review how the oscillatory activities recorded in these structures helped improve our understanding of the sensorimotor brain functions in particular, along with cognitive and emotional-motivational. The oscillations may be classified by frequency into bands at < 8, 8-30 and> 60 Hz. The best characterized band is the 8-30 Hz and existing evidence suggests that it is antikinetic and inversely related to motor processing. On the other hand, accumulating evidence suggests that the > 60 Hz band may be related to normal function.
4
Content available remote Pomiary sygnałów przewodzonych przez włókna nerwowe
PL
W niniejszej pracy przedstawiono stanowisko do badań elektrod typu „cuff” (zewnątrz-nerwowych), oraz uzyskane za jego pomocą wyniki pomiarów charakterystyk przenoszenia elektrod. Zaprezentowano również wyniki badań symulacyjnych wielkości sygnałów, które mogłyby być odbierane za ich pomocą z pojedynczego włókna nerwowego, oraz zdolność tłumienia zakłóceń zewnętrznych.
EN
This work aims at describing a research laboratory for studies on „cuff” type of electrodes and results obtained from measurements of transfer functions have been presented. The work includes results from simulation examinations of signal quantities which might be received from a single nerve fibre. Also capability of examined electrodes to reject external noises was determined.
EN
The purpose of the study was to evaluate the influence of electrical stimulation of nerves innervating the pancreas on the function of the cardiovascular system, lungs and urinary tract, measured as an ECG, blood pressure and pressure in the bladder of a dog. Spiral cuffs with 33 electrodes (1.0 x 2.0 mm) within a silicone sheet were manufactured and implanted in a Beagle dog in the vagus nerve, in the splanchnic nerve and in the pancreatic nerve. Each nerve was stimulated individually with biphasic, rectangular and current pulses (10 mA, 200 [my]s, 20 Hz). When stimuli were 10 mA or higher, measurable changes were observed during stimulation of both the vagus and the splanchnic nerves. In the splanchnic nerve, they were expressed as an increase in pressure in the bladder and as a tremor of the whole stomach. In the vagus nerve, they were expressed as a drastic decrease of arterial blood pressure and as abnormalities in the heart rate. In a further increase of stimuli to about 18 mA, the heart rate was slowed until it ceased as fatal brachicardia, asystolia and consequently hypotensia was occured.
EN
This paper describes physiological phenomena of a electrical stimulation of nerve cell and presents technical issues of electroconvulsive therapy used by psychiatrists.
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