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Network Controllability Analysis of Three Multiple-myeloma Patient Genetic Mutation Datasets

Sanchez Martin Jose Angel, Petre Ion

Fundamenta Informaticae

2020

Vol. 175, nr 1-4

281--299

Network controllability focuses on the concept of driving the dynamical system associated to a directed network of interactions from an arbitrary initial state to an arbitrary final state, through a well-chosen set of input functions applied in a minimal number of so-called input nodes. In earlier studies we and other groups demonstrated the potential of applying this concept in medicine. A directed network of interactions may be built around the main known drivers of the disease being studied, and then analysed to identify combinations of drug targets controlling survivability-essential genes in the network. This paper takes the next step and focuses on patient data. We demonstrate that comprehensive protein-protein interaction networks can be built around patient genetic data, and that network controllability can be used to identify possible personalised drug combinations. We discuss the algorithmic methods that can be used to construct and analyse these networks.

The use of the Hellwig's method for feature selection in the detection of myeloma bone destruction based on radiographic images

Omiotek Zbigniew, Stepanchenko Olga, Wójcik Waldemar, Legieć Wojciech, Szatkowska Malgorzata

Biocybernetics and Biomedical Engineering

2019

Vol. 39, no. 2

328--338

The radiological test is cost-effective, widely available, allows for the visualisation of large areas of the skeleton and can identify long bones potentially at risk for fractures in osteolysis sites. Therefore, radiology is often used in the early stages of multiple myeloma, in the detection and characterisation of complications, and in the assessment of the patient's response to treatment. The accuracy of this method can be improved through the use of appropriate algorithms of computer image processing and analysis. In the study, the feature vector based on humerus CR images was extracted. As a result of the analysis, 279 image descriptors were obtained. Hellwig's method in the selection process was applied. It found the set of feature combinations of the largest integral index of information capacity. To evaluate these combinations, 11 classifiers were built and tested. As a result, 2 feature sets were identified that provided the highest classification accuracy in combination with the K-NN classifier. The 9-NN classifier for the first combination (2 features) was used and 5-NN for the second one (3 features). The classification accuracy (depending on the quality index used) was as follows: overall classification accuracy – 93%, classification sensitivity – 92%, classification specificity – 96%, positive predictive value – 96% and negative predictive value – 93%. Results show that: (1) the use of humerus CR images may be useful in the detection of bone damages caused by multiple myeloma; (2) the Hellwig's method is effective in the feature selection of the analysed kind of images.