Wyniki wyszukiwania - BazTech

1

Functionalized cellulose as a matrix for the synthesis of library of molecular receptors useful for screening of compounds with anti-histamine activity

Walczak M. E., Frączyk J., Kamiński Z. J., Kolesińska B.

Engineering of Biomaterials

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2017

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Vol. 20, no. 142

2--6

EN

The library of molecular receptors was formed by self-organization of N-heptanoylated dipeptides anchored in the regular fashion via aminophenylamino- 1,3,5-triazine linker to the surface of cellulose membrane. SPOT method was used for the synthesis of peptide library. As C-terminal amino acids of peptide fragments were attached: Ala, Pro and Phe, while as a N-terminal amino acids were applied all natural amino acids. DMT/NMM/TosO- was selected as a coupling reagent for synthesis of library of N-heptanoylated dipeptides. These constructs were used as a tool for distinguishing pharmaceutically active compounds acting on histamine receptors. In the studies as active compounds were tested: Doxylamine and Difenhydramine with histamine agonist activity, Ranitidine and Cimetidine with antagonist activity as well as Histamine – natural ligand. The binding of colourless ligands was monitored by staining with Brilliant Black used as reporter dye and quantitative colour measurement was performed in 256 grade gray scale by using Image-Quant software. Substantial differences in the ability of interactions of agonists and antagonists with bounding pockets were observed with selected molecular receptors. From 60 elements library of molecular receptors were selected 12, which were able to distinguish between agonists or antagonists. It has been found that even small changes (Leu residue vs Val residue) in the structure of molecular receptor influenced specificity of agonist or antagonist binding.

2

Cellulose as a matrix for synthesis of the library of molecular receptors useful for screening of antihistamine compounds

Walczak M. E., Fraczyk J., Kaminski Z. J., Kolesinska B.

Engineering of Biomaterials

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2017

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Vol. 20, no. 143 spec. iss.

50

3

Funkcjonalne hybrydowe nanomateriały - od pomysłu poprzez laboratorium do biznesu

Schroeder G., Łęska B., Kurczyńska J.

Chemik

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2012

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Vol. 66, nr 3

196-205

PL

Funkcjonalne materiały na bazie receptorów molekularnych, to nowy dynamicznie rozwijający się kierunek w chemii. Poznanie zasad wzajemnego oddziaływania cząsteczek, opanowanie wydajnych metod syntezy oraz umiejętność przewidywania właściwości materiałów zawierających receptory molekularne, stworzyły realne podstawy do realizacji projektów od pomysłu, poprzez badania podstawowe do komercyjnego zastosowania. W artykule przedstawiono drogę od idei do materiału użytkowego, którego właściwości zależą od natury receptora molekularnego. Dla wybranych układów przedstawiono komercyjne zastosowanie hybrydowych nanomateriałów nieorganiczno-organicznych.

EN

Functionalized materials, based on molecular receptors, determine new direction of dynamic development in chemistry. The knowledge about interactions between molecules, the control of efficient synthesis methods and the ability of properties prediction of materials carrying molecular receptors, generate real foundation for the fulfillment of projects started from the concept, through the research studies, to commercial application. The paper describes the way from the idea to the material, which properties depend on the nature of a molecular receptor. It also includes commercial applications of some hybrid inorganic-organic nanomaterials.

4

The Synthesis and Structure of Diaza- ans Tetraazacoronands

Lipkowski P., Urbańczyk-Lipkowska Z., Jurczak J.

Polish Journal of Chemistry

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2002

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Vol. 76 / nr 5

729-736

EN

A general method of the synthesis of simple azacoronands via the amidation reaction is presented. Several examples of the X-ray structure studies of the compounds obtained are given.