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1
Content available remote Unparalleled and revolutionary impact of PET imaging on research and day to day practice of medicine
Alavi Abass, Werner Thomas J., Stępień Ewa Ł., Moskal Paweł
Bio-Algorithms and Med-Systems
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2021
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Vol. 17, no. 4
203--212
EN
Positron emission tomography (PET) imaging is the most quantitative modality for assessing disease activity at the molecular and cellular levels, and therefore, it allows monitoring its course and determining the efficacy of various therapeutic interventions. In this scientific communication, we describe the unparalleled and revolutionary impact of PET imaging on research and day to day practice of medicine. We emphasize the critical importance of the development and synthesis of novel radiotracers (starting from the enormous impact of F-Fluorodeouxyglucose (FDG) introduced by investigators at the University of Pennsylvania (PENN)) and PET instrumentation. These innovations have led to the total-body PET systems enabling dynamic and parametric molecular imaging of all organs in the body simultaneously. We also present our perspectives for future development of molecular imaging by multiphoton PET systems that will enable users to extract substantial information (owing to the evolving role of positronium imaging) about the related molecular and biological bases of various disorders, which are unachievable by the current PET imaging techniques.
2
Content available remote Perspectives of brain imaging with PET systems
Majewski Stan
Bio-Algorithms and Med-Systems
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2021
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Vol. 17, no. 4
269--291
EN
In this partial review and partial attempt at vision of what may be the future of dedicated brain PET scanners, the key implementations of the PET technique, we postulate that we are still on a development path and there is still a lot to be done in order to develop optimal brain imagers. Optimized for particular imaging tasks and protocols, and also mobile, that can be used outside the PET center, in addition to the expected improvements in sensitivity and resolution. For this multi-application concept to be more practical, flexible, adaptable designs are preferred. This task is greatly facilitated by the improved TOF performance that allows for more open, adjustable, limited angular coverage geometries without creating image artifacts. As achieving uniform very high resolution in the whole body is not practical due to technological limits and high costs, hybrid systems using a moderate-resolution total body scanner (such as J-PET) combined with a very high performing brain imager could be a very attractive approach. As well, as using magnification inserts in the total body or long-axial length imagers to visualize selected targets with higher resolution. In addition, multigamma imagers combining PET with Compton imaging should be developed to enable multitracer imaging.
3
Content available remote A literature review on multimodality molecular imaging nanoprobes for cancer detection
Shahbazi-Gahrouei Daryoush, Moradi Khaniabadi Pegah, Shahbazi-Gahrouei Saghar, Khorasani Amir, Mahmoudi Farshid
Polish Journal of Medical Physics and Engineering
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2019
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Vol. 25, Iss. 2
57--68
EN
Molecular imaging techniques using nanoparticles have significant potential to be widely used for the detection of various types of cancers. Nowadays, there has been an increased focus on developing novel nanoprobes as molecular imaging contrast enhancement agents in nanobiomedicine. The purpose of this review article is to summarize the use of a variety of nanoprobes and their current achievements in accurate cancer imaging and effective treatment. Nanoprobes are rapidly becoming potential tools for cancer diagnosis by using novel molecular imaging modalities such as Ultrasound (US) imaging, Computerized Tomography (CT), Single Photon Emission Tomography (SPECT) and Positron Emission Tomography (PET), Magnetic Resonance Imaging (MRI), and Optical Imaging. These imaging modalities may facilitate earlier and more accurate diagnosis and staging the most of cancers.
4
Content available Zastosowanie PET/CT w neurologii
Cegła Paulina, Chrapko Beata, Pietrasz Katarzyna, Cholewiński Witold
Inżynier i Fizyk Medyczny
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2019
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Vol. 8, nr 2
79--83
PL
Pozytonowa tomografia emisyjna w połączeniu z tomografią komputerową (positron emission tomography/computed tomography, PET/CT) jest techniką dostarczającą informacji na temat różnych procesów zachodzących w ośrodkowym układzie nerwowym (OUN). Pozwala na ocenę metabolizmu glukozy (18F-fluorodeoksyglukoza, 18F-FDG), układu dopaminergicznego (18F-DOPA) czy wychwytu aminokwasów (18F-fluoroetylotyrozyna, 18F-FET). Celem niniejszej pracy jest omówienie zastosowania techniki PET/CT w zaburzeniach neurologicznych w oparciu o analizę piśmiennictwa.
EN
Positron emission tomography/computed tomography (PET/ CT) is an imaging technique used for assessment of different metabolic processes of central nervous system (CNS). Allows to evaluate glucose metabolism (18F-Fluorodeoxyglucose, 18F-FDG), dopaminergic pathway integrity (18F-dihydroxyphenylalanine, 18F-DOPA) and amino acid uptake (18F-fluoroethylo-thyrosine, 18F-FET). The aim of this review is to discuss the usefulness of the PET/CT method in the neurological disorders based on literature review.
5
Content available Development of magnetic nanoparticles tomography in nuclear and medical electronics division
Wróblewski P., Smolik W.
Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska
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2017
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T. 7, nr 1
125--129
EN
In this article summary of all accomplishments of Nuclear and Medical Electronics Division in the field of Magnetic Nanoparticles Imaging. Magnetic Nanoparticles Imaging is a new tomographic and molecular imaging method that employs superparamagnetic nanoparticles as the tracer. This article includes the most importuned definition regarding this technique, its most interesting features, as well as report about research conducted in the Division in prospect to advance this imaging method in Poland.
PL
Artykuł ten podsumowuje dotychczasowe osiągnięcia Zakładu Elektroniki Jądrowej i Medycznej w dziedzinie obrazowania nanocząsteczek magnetycznych. Obrazowanie nanocząsteczek magnetycznych jest to nowa metoda obrazowania molekularnego i tomograficznego wykorzystująca jako znacznik nanocząsteczki superparamagnetyczne. W treści artykułu zawarto najważniejsze definicje dotyczące tego zagadnienia. Obecny stan rozwoju tej techniki oraz jej najbardziej interesujące właściwości, jak również opis prac badawczych podjętych przez Zespół w celu rozwoju tej metody obrazowania w Polsce.
6
Content available remote Hiperpolaryzacyjne związki kontrastujące w obrazowaniu MRI : przygotowanie kontrastu
Lorenc K., Nieciecki M., Cacko M., Czarniecki M., Zalewska E., Królicki L.
Inżynier i Fizyk Medyczny
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2015
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Vol. 4, nr 5
245--248
PL
Zastosowanie kontrastów hiperpolaryzacyjnych jest znaczącym krokiem w rozszerzeniu zastosowań MRI w zakresie obrazowania molekularnego. W artykule przedstawiono niezbędne i zalecane wyposażanie pracowni prowadzącej badania z wykorzystaniem kontrastów hiperpolaryzacyjnych, a także proces przygotowania próbki do hiperpolaryzacji.
EN
The application of hyperpolarized contrasts in MRI is a step towards molecular imaging. This article discusses the prerequisites and recommended laboratory apparatus for implementing hyperpolarized contrast agents’ use in diagnostics. The process of sample preparation is described and basic concepts in DNP polarization are introduced.
7
Content available remote Positron emission tomography (PET) in oncology: current applications and future perspectives
Trofimiuk-Müldner M., Hubalewska-Dydejczyk A.
Bio-Algorithms and Med-Systems
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2014
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Vol. 10, no. 1
47--52
EN
Positron emission tomography (PET), particularly dual-modality imaging systems (PET/CT or PET/MRI), has evolved from being a research tool into a valuable clinical modality, particularly in the field of oncology. Currently, most of the PET/CT examinations are done with FDG when assessing glucose metabolism in tumors. FDG PET or PET/CT has been proven to be a valuable method in staging, restaging, therapy response assessment, early recurrence detection, and in unknown primary focus localization. However, PET/CT has its limitations, leading to both false-positive and false-negative results. Proper design and/or choice of an alternative tracer may overcome those problems as well as give better insight into tumor biology and result in more thorough assessment and effective therapeutic approach in patients with cancer.
8
Content available Optyczne metody obrazowania molekularnego
Sołtysiński T., Liebert A., Zawicki I., Maniewski R.
Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna
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2008
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Vol. 14, nr 4
331--335
PL
Obrazowanie molekularne jest szybko rozwijającą się dziedziną badań w zakresie biotechnologii i inżynierii biomedycznej. W artykule przedstawiono przegląd technik stosowanych w obrazowaniu molekularnym, wykorzystujących metody medycyny nuklearnej oraz optyczne techniki oparte na analizie promieniowania fluorescencyjnego. W szczególności opisano metody optyczne obrazowania molekularnego stosowane w skali mikroskopowej (mikroskopia konfokalna, obrazowanie czasu relaksacji fluorescencyjnej, transfer energii Foerstera) oraz wykorzystywane w badaniach na zwierzętach doświadczalnych. Omówiono także potencjalne wykorzystanie technik optycznych w badaniach dużych objętości tkanek.
EN
Molecular imaging (MI) is a rapidly emerging field of biomedical, biotechnological and engineering research. This study provides a brief review of the state-of-the-art techniques and methods of MI based on nuclear physics and fluorescent agents. Special attention will be focused on optical methods of MI applied in microscopic scale (multiphoton confocal microscopy, fluorescence lifetime imaging, Forster energy transfer) and in experimental animals. Potential application of MI in large tissue volumes will be also discussed.
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