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1

Polyethylene Oxide and their Antibacterial Effects Against some Pathogenic Bacteria

Abbas Abtisam Jasim, Al-Alaq Farah Tareq, Abdulazee Lubna, Naje Ahmed Samir

Ecological Engineering & Environmental Technology

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2022

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Vol. 23, iss. 6

26--31

EN

Poly ethylene oxide is an uncrosslinked, non-ionic linear hydrophilic polymer with a variety of molecular weights. PEO is used to make it, and it offers a number of beneficial qualities for medication delivery and antibacterial uses. The antibacterial activity of polyethylene oxide (PEO) at various concentrations as (80, 40, 20, 10 g/ml) against bacteria in Gram-positive Staphylococcus aureus, Streptococcus pyogenes and Lactobacillus sp. and Gram-negative Enterobacter bugandensis, E. coli, Pseudomonas aeruginosa and Klebsiella pneumonia was investigated in this study. The disk diffusion experiment was used to assess the antimicrobial activity of PEO, as well as each isolate’s minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). PEO is shown to have strong broad-spectrum antibacterial action against the bacteria studied, that inhibition zone increase their width inversely proportional to PEO concentration, and has even outpaced the efficacy of certain medicines. PEO had MICs ranging from 10 to 20 g/ml, as well as MBCs of 20 to 80 g/ml. In additional studies, PEO was discovered to be strongly associated with the cell of bacteria, which contributed to its inhibitory impact on bacterial invasion and growth. PEO at an appropriate dose effectively decreased bacterial growth. PEO is highly recommended as a cost-effective antibacterial treatment, Specifically, ectopic infection treatment without the risk of bacterial strains becoming antibiotic-resistant.

2

Ocena lekowrażliwości czynników etiologicznych zakażeń układu moczowego

Sztucki Damian

Laboratorium Medyczne

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2020

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nr 1

34--39

PL

ZUM, czyli zakażenia układu moczowego, należą do najczęściej występujących chorób infekcyjnych u ludzi, szczególnie u dzieci. W grupie drobnoustrojów chorobotwórczych odpowiedzialnych za te zakażenia wyróżnia się Gram-ujemne pałeczki z rodzaju Enterobacteriaceae, między innymi: Escherichia coli, Klebsiella spp. i Proteus spp. Podatność na wystąpienie choroby i tym samym zmianę charakterystyki flory fizjologicznej organizmu zależą od wieku, płci i historii osoby narażonej na zakażenie. Antybiogramy to wyniki badania wrażliwości danego drobnoustroju na działanie konkretnego antybiotyku lub klasy antybiotyków oraz chemioterapeutyków. Ocena lekowrażliwości mikroorganizmów wywołujących ZUM stanowi podstawę w doborze odpowiedniej terapii, co może doprowadzić do skrócenia czasu i sukcesu leczenia.

EN

UTIs, i.e. urinary tract infections, are among the most common infectious diseases in humans, especially children. In the group of pathogenic microorganisms responsible for these infections, Gram-negative rods of the genus Enterobacteriaceae are distinguished, among others: Escherichia coli, Klebsiella spp. and Proteus spp. Susceptibility to a disease and thus a change in the characteristics of the physiological flora of the body depends on the age, sex and medical history of people at risk of infection. Antibiograms are the results of testing the sensitivity of a given microorganism to the action of a specific antibiotic or a class of antibiotics and chemotherapeutics. The assessment of the drug susceptibility of microorganisms causing UTI is the basis for well-suited therapy, which can lead to a reduction in the time of treatment and its success.

3

Synthesis and antibacterial properties of quaternary ammonium derivative of polyethylenimine

Kwolek U., Wójcik K., Janiczek M., Nowakowska M., Kepczynski M.

Polimery

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2017

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T. 62, nr 4

311--316

EN

The quaternary derivative of branched polyethylenimine (bPEI-met) was synthesized and its antibacterial activity against Gram-positive bacterium (Staphylococcus aureus) and Gram-negative bacterium (Escherichia coli) was studied. The values of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of bPEI-met against mentioned bacteria were determined. These indicated that bPEI-met could be considered as an effective alternative to antibiotics for the treatment of selected bacterial strains. The results obtained can be useful in search for drugs allowing treatment of antibiotic resistant bacterial strains.

PL

Zsyntetyzowano czwartorzędową amoniową pochodną rozgałęzionej polietylenoiminy (bPEI-met) i badano jej działanie antybakteryjne przeciwko bakteriom Gram-dodatnim na przykładzie gronkowca złocistego (Staphylococcus aureus) i Gram-ujemnym na przykładzie pałeczki okrężnicy (Escherichia coli). Wyznaczono wartości minimalnego stężenia hamującego (MIC) i minimalnego stężenia bakteriobójczego (MBC) bPEI-met w stosunku do obu wymienionych szczepów bakterii. Wyniki tych badań sugerują, że bPEI-met może być rozważana jako alternatywa dla antybiotyków w zwalczaniu wybranych szczepów bakterii, szczególnie tych, które charakteryzują się antybiotykoopornością.

4

Antibacterial Activities of Some Transition Metal Schiff Base Complexes

Islam M.N., Shahriar S.M.S., Islam M.K., Jesmin M., Ali M.M., Khanam J.A.

International Letters of Chemistry, Physics and Astronomy

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2013

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Vol. 5

12-20

EN

A new series of four transition metal complexes of a Schiff base derived from salicylaldehyde and glycine, viz. [N-salicylidene glycinato diaqua cobalt (II) dimer] (SGCo)2, [N- salicylideneglycinato-di-aqua-nickel(ll)dimer] (SGN)2, [N-salicylideneglycinato-aqua-copper(II)] (SGC) and [N-salicylidene glycinato diaqua zinc(II) dimer] (SGZ)2 have been synthesized and characterized through a rapid, simple, and efficient methodology in excellent yield. These compounds were screened for in vitro antibacterial activities against six pathogenic bacteria, such as Shigella sonnei, Escherichia coli, Bacilus subtilis, Sarcina lutea, Staphylococcus aureus and Pseudomonas arioginosa. The antibacterial activity was determined by the disc diffusion method using DMSO as solvent. The results indicate that (SGC) compound exhibit a significant antibacterial activity, depending on the bacterial strain and (SGCo)2, (SGN)2 and (SGZ)2 compounds show a moderate sensitivity even with higher doses. All these compounds were found to possess cytotoxic effect.