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EN
Micro-electrical discharge machining (micro-EDM) is a potential non-contact method for fabrication of biocompatible micro devices. This paper presents an attempt to model the tool electrode wear in micro-EDM process using multiple linear regression analysis (MLRA) and artificial neural networks (ANN).The governing micro-EDM factors chosen for this investigation were: voltage (V), current (I), pulse on time (Ton) and pulse frequency (f). The proposed predictive models generate a functional correlation between the tool electrode wear rate (TWR) and the governing micro-EDM factors. A multiple linear regression model was developed for prediction of TWR in ten steps at a significance level of 90%. The optimum architecture of the ANN was obtained with 7 hidden layers at an R-sq value of 0.98. The predicted values of TWR using ANN matched well with the practically measured and calculated values of TWR. Based on the proposed soft computing-based approach towards biocompatible micro device fabrication, a condition for the minimum tool electrode wear rate (TWR) was achieved.
PL
Miniaturyzacja obejmuje swym zakresem znaczną część sprzętu laboratoryjnego, którego klasyczne odpowiedniki są obecne we współczesnych laboratoriach. Dzięki zastosowaniu nowoczesnych technologii możemy osiągnąć duże oszczędności związane ze zminiaturyzowaniem sprzętu poprzez znaczne ograniczenie liczby odczynników, czasu analizy i czasu pracy przy zachowaniu tej samej dokładności pomiarów.
EN
Miniaturization includes within its scope a large part of laboratory equipment, whose classical counterparts are present in modern laboratories. Thanks to modern technology, we can achieve significant savings associated with miniturized equipment by reducing the amount of reagents, work time and analysis time while maintaining the same measurement accuracy.
4
Content available Miniaturized device for a cell lysis process
EN
Single-cell studies are crucial for gaining knowledge on complexity of intracellular processes. In many cases, carrying researches into cell ingredients must be proceeded by a lysis process. Cell lysis leads to disintegration of the plasma membrane which is the barrier separating cell contents from the environment. However, investigations at the cellular level would not be possible without proper miniaturized tools, which offer many advantages as low reagents consumption, short reaction time, integration, automation or versatility. The goal of this work was to design and develop a microfluidic chip for a chemical cell lysis process. The geometry of a microsystem presented is based on the hydrodynamic focusing of a cell suspension stream. Applying non-denaturing cell lysis buffer enables to analyze released cell ingredients during next steps of investigations.
5
Content available remote Energetic Behavior of a MEMS Microturbine Concept
EN
The energetic behavior of a MEMS based microturbine concept is analysed by applying a model that accounts for strong heat mixing in the microengine. The results give some understanding on the possibilities to obtain a usable power from this microdevice.
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