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Review on the numerical investigations of mass transfer from drug eluting stent

Song Jianfei, Kouidri Smaine, Bakir Farid

Biocybernetics and Biomedical Engineering

2021

Vol. 41, no. 3

1057--1070

Drug-eluting stent (DES) as the newly developed treatment for the cardiovascular disease has been the preferred treatment option for most of the patients with significant reduction of restenosis incidents. However, the follow-up complications such as late thrombosis after stent implantation limit the further widespread use of DES which has caused extensive attention from the researchers. Numerical method has been widely employed to predict the DES performance in human body during the past decades, contributing to the stent design optimization and a better understanding of drug release mechanisms in a cost-effective way compared to the experiments. Among the existing numerical investigations, different modelling methods of DES inside artery can be found to study the drug transport process, and adopting the proper models physically and mathematically plays a key role to obtain the results well fitting with the practical case. Therefore, in this review article, the existing numerical researches regarding DES mainly in the last two decades have been focused and summarized including the established modeling methods and the controlling parameters investigations related to drug release from DES. In addition, the common results obtained have been discussed collectively aiming to guide the following researches.