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The influence of selected transition elements on cell metabolism

Terpiłowska Sylwia, Rafińska Katarzyna, Gołębiowski Adrian, Kowalkowski Tomasz, Buszewski Bogusław

Ecological Chemistry and Engineering. S

2023

Vol. 30, nr 4

471--488

The elements are present in the environment. Moreover, they are used in pharmacy and the production of new materials used in medical applications. They are often as environmental pollutants. They can accumulate in organisms and induce toxic effects on the cellular level. HepG2, L929 and Caco-2 cell lines were exposed to known concentrations of chromium chloride, iron chloride, nickel chloride, molybdenum trioxide and cobalt chloride (200 or 1000 μ M used alone and in combinations). Concentrations of chromium, iron, nickel, molybdenum and cobalt in the cell lysate and the culture medium were determined by ICP-MS. Moreover, sodium, potassium, calcium and magnesium concentrations were also measured. What is more, cells were observed under light and scanning electron microscope. The dose-dependent increase in the concentration of chromium, iron, nickel, molybdenum and cobalt in all cell lines after incubation with elements was observed. Potassium concentration decreases while sodium calcium and magnesium increase after incubation of cells with of mentioned elements. The incubation of cells with microelements induces cell morphology changes. The presented study shows the crucial role of tested microelements in the induction of cell death as a result of an imbalance of sodium, potassium, calcium and magnesium concentration inside the cell.

Komórkowe efekty oddziaływania wolnozmiennych pól magnetycznych

Sieroń A., Kawczyk-Krupka A.

Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna

1998

Vol. 4, nr 3

79-85

Prace eksperymentalne na modelu komórkowym wykazują różnorodne działanie biologiczne wolnozmiennych pól magnetycznych, zależnie od parametrów fizycznych pól: indukcji, częstotliwości, kształtu fali oraz od czasu ekspozycji. Wolnozmienne pola magnetyczne modyfikują różnorodne funkcje życiowe, ekskrecję, podziały komórkowe, a także ekspresje genów. Eksperymenty przeprowadzane na hodowlach komórkowych pozwalają na obiektywną ocenę efektu działania wolnozmiennych pól magnetycznych na struktury subkomórkowe.

Experimental studies at the cellular level have demonstrated various biological effects of the magnetic fields. Studies with cellular systems using different exposure regimes durations, amplitudes, frequencies and waveforms indicate, that biological effects of magnetic fields on cellular systems may be related to cell viability, multiplication, gene expression, cellular excretion, or even tumour promotion. The experiments performed on tissue cultures seem to give better insight into the effects evoked by magnetic field within a single cell and its subcellular organelles.