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1 2004

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Transient Permeability Induced by Cationic Derivatives of Amphotericin B in Lipid Membranes

Kasumov K., Bolard J.

Polish Journal of Chemistry

2004

Vol. 78 / nr 8

1057-1065

Individual ionic channels were shown to be formed through brain phospholipid membranes containing cholesterol, by two-sided addition of cationic derivatives of amphotericin B. At concentrations between 10-8 and 10-7 M, the resulting conductance appeared to be transient. Equilibrium between different antibiotic assemblies inside the membrane was demonstrated by the kinetics of conductance decrease following washing out the antibiotic. To explain the transient characteristics of the induced conductance, it is proposed that the antibiotic, present in solution under self-associated form, binds the membrane and forms pores, then dissociates in the bilayer in a non active monomeric form. This observation may be of importance to explain the delivery of oligonucleotides into mammalian cells, by cationic derivatives of amphotericin B.