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Simulation on human respiratory motion dynamics and platform construction

Bao Yudong, Li Xu, Wei Wen, Qu Shengquan, Zhan Yang

Biocybernetics and Biomedical Engineering

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2023

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Vol. 43, no. 4

736--750

EN

Bronchoscopy has a crucial role in the current treatment of lung diseases, and it is typical of interventional medical instruments led by manual intervention. The scientific study of bronchoscopy is now of primary importance in eliminating problems associated with manual intervention by scientific means. However, for its intervention environment, the trachea is often treated statically, without considering the effect of tracheal deformation on bronchoscopic intervention during respiratory motion. Therefore its findings can deviate from practical application. Thus, studying kinetic problems in respiratory motion is of great importance. This paper developed a mathematical model of mechanical properties of respiratory motion to express respiratory force from the perspective of dynamics of respiratory motion. The dynamical model was solved using MATLAB. Then, a finite element model of respiratory motion was built using Mimics, and the results of respiratory force solution were used as the load of model for dynamics simulation in ABAQUS. Then, a human–computer interaction platform was designed in MATLAB APP Designer to realize parametric calculation and fitting of respiratory force, and a personalized human respiratory motion dynamics simulation was completed in conjunction with ABAQUS. Finally, experimental validation of the interactive platform was performed using pulmonary function test data from three patients. Validation analysis by respiration striving solution, kinetic simulation and experiment found that Dynamical model and simulation results can be better adapted to the individualized study of human respiratory motion dynamics.

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Modelowanie stanu mechaniki układu oddechowego u osób otyłych

Redlarski G., Jaworski J.

Pomiary Automatyka Kontrola

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2013

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R. 59, nr 3

266--269

PL

Przedmiotem publikacji jest przedstawienie propozycji modelowania i zasad wizualizacji zmian w mechanice układu oddechowego, u osób z nadwagą lub otyłością. W badaniach wykorzystano 16-elementowy model elektryczny układu oddechowego. Dobór wartości parametrów modelu odbywał się na podstawie wiedzy dostępnej w literaturze medycznej. Opracowanie może być szczególnie przydatne inżynierom dokonującym wstępnej weryfikacji nowo opracowywanych systemów medycznych lub na etapie dokonywania przeglądów okresowych aparatury medycznej.

EN

The subject of the publication is a proposal of approach to modeling and visualization of changes in pulmonary mechanics, for people impaired by obesity or serious overweight. Previously developed models of the patient respiratory system were based on parameter identification of the considered models with the help of the measured data [3]. In this paper the modeling procedures basing on the basic medical knowledge in the field of clinical obesity (BMI> 35) are proposed. In the research a 16-coefficient electrical model of the respiratory system (Fig. 1), presented previously in [8], was used Most of lesions causing the changes in parameter values, described in Section 2, simulate the changes in mechanics of respiratory tract and lungs. The range and nature of the changes in the model parameter values are the subject of Section 3. The results of simulations of the respiratory volume (Fig. 3) and the flow (Fig. 4) are presented in Section 4. Moreover, the result of respiratory mechanics examination obtained by FOT is shown in Fig. 6. The presented time courses are consistent with the results available in the medical literature, obtained as a result of the medical examinations (Fig. 5). That proves the legitimacy of the presented approach and demonstrates the functionality of lesions modeling based on basic medical knowledge. This approach may be particularly useful for engineers providing preliminary verification of newly developed medical systems or at the stage of servicing the medical equipment.

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The effect of body warming on respiratory system stress recovery in the rat

Rubini A., Carniel E.L., Natali A.N.

Acta of Bioengineering and Biomechanics

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2012

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Vol. 14, no. 3

59-66

EN

The mechanical characteristics of respiratory system tissues include visco-elastic behaviour. In particular, after mechanical unloading, i.e., a reduction in respiratory system volume, the lower stress achieved slowly increases, approaching higher constant value, due to visco-elastic stress recovery. We performed experiments in which constant deflation flow arrest was applied in rats to study the successive pressure-time course, which defines the visco-elastic stress recovery. To investigate the possible effects of temperature changes, measurements were performed at two body temperatures, 36.6 +- 0.3 and 39.0 +- 0.1 degrees C. We found that stress recovery is reduced by increasing body temperature. Pressure-time curves after deflation arrest were fitted by specific mathematical model, and a good agreement was found. Model parameters exhibited significant changes with body temperature variations, suggesting that temperaturedependent micro-structural rearrangement phenomena in the tissues of alveolar wall were involved in the stress recovery decrement with body temperature increase. Thus, visco-elastic phenomena in respiratory system tissues of mammals exhibit temperature dependence. The stress recovery changes with body temperature suggest that expiration is expected to be easier in condition of physiological body temperature than in the case of increased temperature.