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Content available remote Dynamic surface tension as an indicator of lung function in health and disease
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The paper summarizes recent achievements in the using the techniques of determination of dynamic surface tension for the evaluation of quality of the pulmonary surfactant (PS). Based on the essential information on physical chemistry of the PS system, the importance of the dynamic surface activity of the surfactant for physiological functions of the lungs is demonstrated and the experimental methods for studying those properties in vitro are presented. Several examples of applications of dynamic tensiometry for assessment the PS functions are shown, including the research on toxicity of inhaled air polutants, approach to diagnosis the pulmonary diseases and interactions with PFCs used in partial liquid ventilation. The perspectives of future applications of physicochemical methods in pulmonary surfactant research (e.g., development of surfactant supplementation therapy) are suggested.
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