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The role of the bone strength on the cyst growth in the mandible

Miodowska Justyna, Bielski Jan, Kromka-Szydek Magdalena

Engineering Transactions

2019

Vol. 67, iss. 3

293--300

Intracystic fluid pressure is discussed as a potentially important factor influencing a bone cyst growth. This process can develop in the course of months. However, the exact mechanism remains speculative. In this paper, we use an established mathematical model to evaluate whether the presence of pressurized fluid in bone cavities may result in cyst growth. A continuous function of bone density rate vs. mechanical stimulus is used. The numerical model of the mandible with the cyst is used to predict the stress-stimulated change in bone density around the cavity.

Optimization of differentiation time of mesenchymal-stem-cell to tenocyte under a cyclic stretching with a microgrooved culture membrane and selected measurement cells

Morita Y., Yamashita T., Toku Y., Yu Y.

Acta of Bioengineering and Biomechanics

2018

Vol. 20, no. 1

3--10

There is a need for efficient stem cell-to-tenocyte differentiation techniques for tendon tissue engineering. More than 1 week is required for tenogenic differentiation with chemical stimuli, including co-culturing. Research has begun to examine the utility of mechanical stimuli, which reduces the differentiation time to several days. However, the precise length of time required to differentiate human bone marrow-derived mesenchymal stem cells (hBMSCs) into tenocytes has not been clarified. Understanding the precise time required is important for future tissue engineering projects. Therefore, in this study, a method was developed to more precisely determine the length of time required to differentiate hBMSCs into tenocytes with cyclic stretching stimulus. Methods: First, it had to be determined how stretching stimulation affected the cells. Microgrooved culture membranes were used to suppress cell orientation behavior. Then, only cells oriented parallel to the microgrooves were selected and evaluated for protein synthesis levels for differentiation. Results: The results revealed that growing cells on the microgrooved membrane and selecting optimally-oriented cells for measurement improved the accuracy of the differentiation evaluation, and that hBMSCs differentiated into tenocytes in approximately 10 h. Conclusions: The differentiation time corresponded to the time required for cellular cytoskeleton reorganization and cellular morphology alterations. This suggests that cells, when subjected to mechanical stimulus, secrete mRNAs and proteins for both cytoskeleton reorganization and differentiation.

Kompozycje wybuchowe o obniżonej wrażliwości na bodźce mechaniczne

Szymańczyk L., Trzciński W. A.

Problemy Techniki Uzbrojenia

2003

R. 32, z. 86

157--165

W pracy zbadano właściwości detonacyjne nowych kompozycji wybuchowych zawierających NTO (3-Nitro-1,2,4-triazol-5-on), trotyl i heksogen. Wyznaczono ich parametry energetyczne i detonacyjne. Określono wrażliwość na bodźce mechaniczne: uderzenie i falę uderzeniową.

Detonating properties of some new explosive compositions consisting of NTO, trotyl, and hexogen are presented. Their energetic and detonating characteristics and also susceptibility against mechanical impact like shock wave were measured.