Wyniki wyszukiwania - BazTech

1

Ocena toksyczności wybranych pestycydów, ich metabolitów i zanieczyszczeń produkcyjnych w stosunku do białych i czerwonych krwinek człowieka

Huras B., Sosnowska B., Kwiatkowska B., Bukowska B.

Przemysł Chemiczny

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2016

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T. 95, nr 12

2418--2421

PL

Przedstawiono wyniki badań wpływu dwóch insektycydów (bromfenwinfos i chlorfenwinfos) oraz herbicydu glifosat, a także ich metabolitów oraz zawartych w preparatach pestycydowych potencjalnych zanieczyszczeń, na erytrocyty i jednojądrzaste komórki krwi człowieka (głównie limfocyty).

EN

Chem. and physiol. properties of bromfenvinphos, chlorfenvinphos and glyphosate were reviewed with 22 refs. Their metabolites and potential impurities were also taken into consideration.

2

Potransfuzyjna choroba przeszczep przeciwko biorcy

Lachert E.

Laboratorium - Przegląd Ogólnopolski

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2006

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nr 10

46--49

PL

Choroba przeszczep przeciwko biorcy (TA-GvHD) jest rzadkim, ale groźnym powikłaniem. Warunkiem jego wystąpienia jest przetoczenie żywotnych limfocytów T, które proliferują w organizmie biorcy, a system immunologiczny jest niezdolny do ich zniszczenia. Najważniejszymi czynnikami związanymi bezpośrednio z ryzykiem wystąpienia TA-GvHD są: stan odporności pacjenta i jego zdolność do odpowiedzi immunologicznej, stopień pokrewieństwa w zakresie antygenów zgodności tkankowej (HLA) pomiędzy dawcą i biorcą, a także ilość żywotnych limfocytów dawcy obecnych w składnikach krwi. Ponieważ leczenie powikłania jest nieskuteczne, należy prowadzi działania zapobiegawcze polegające na napromienianiu komórkowych składników krwi przed transfuzją.

EN

Transfusion-associated graft-versus-host disease (TA-GvHD) is a rare, but usually fatal complication that occur when viable done T lymphocytes proliferate and engraft in susceptible patient after transfusion of whole blood and cellular components. At least three factors appear to be directly related to the risk of TA-GvHD are: 1) the susceptibility of patient's immune system to the engraftment, 2) the degree of HLA similarity between donor and recipient, and 3) the number of viable donor lymphocytes present in the transfuses components. There is no effective treatment for TA-GvHD , and the irradiation of cellular blood components before transfusion have been only proven method of preventing this reaction.

3

Efficiency of a 252Cf source in normal or in B-10 enriched lymphocytes evaluated by SCGE assay, classical cytogenetics and FISH technique

Cebulska-Wasilewska A., Niedźwiedź W., Florjan D., Schneider K., Kopec M., Kreft A.

Nukleonika

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2001

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Vol. 46, nr 2

41-49

EN

Biological effectiveness of a californium-252 source was evaluated after irradiations in vitro of normal or pretreated cells with compound enriched in the B-10 ion (Na210B12H11SH also known as BSH) in order to check the possibility of any enhancement effect due to the process of boron neutron capture. Peripheral blood lymphocytes were used as a model for human cells. Human blood samples or isolated lymphocytes were irradiated with the isotopic source of 252Cf, at the Faculty of Physics and Nuclear Techniques at the University of Mining and Metallurgy, Kraków, (both the neutron source and the samples were placed in an "infinite" polyethylene block). DNA and chromosomal damage were studied to compare the biological effectiveness of irradiation. Single cell gel electrophoresis also known as the Comet assay was done to investigate the DNA damage. Classical cytogenetic analysis was applied to assess the frequencies of unstable aberrations (dicentrics, rings and acentric fragments). To evaluate the frequencies of stable aberrations the fluorescence in situ hybridisation (FISH) with probes for chromosomes 1, 4 (14,3% of the whole genome) was performed. Linear (or close to linear) increases with radiation doses were observed for the DNA damage and aberration frequencies in lymphocytes both untreated or pretreated with BSH. Levels of translocations evaluated for the whole genome were comparable with the frequencies of dicentrics and rings. No significant differences were detected due to radiation dose in the frequencies of sister chromatid exchanges (SCE) detected in the second mitosis. Statistically no significant differences were observed in various biological end-points between normal or boron pre-treated cells.