Wyniki wyszukiwania - BazTech

Ograniczanie wyników

1 Acta Chromatographica

1 2008

Znaleziono wyników: 1

Liczba wyników na stronie

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych: lercanidipine

Sortuj według:

Ogranicz wyniki do:

Simultaneous TLC-densitometric analysis of atenolol and lercanidipine hydrochloride in tablets

Deore P. V., Shirkhedkar A. A., Surana S. J.

Acta Chromatographica

2008

Vol. 20, no. 3

463-473

A new simple, precise, accurate, and selective thin-layer chromatographic (TLC) method has been developed for simultaneous analysis of atenolol and lercanidipine hydrochloride in a tablet dosage form. Chromatographic separation was achieved on aluminum foil plates precoated with silica gel 60F 254 , with toluene-methanoltriethylamine 3.5:1.5:0.1 (v/v) as mobile phase. Detection was performed densitometrically at 275 nm. The R F of atenolol and lercanidipine hydrochloride were 0.24 and 0.68, respectively. The reliability of the method was assessed by evaluation of linearity (2000-12000 ng per band for atenolol and 400-2400 ng per band for lercanidipine hydrochloride), accuracy (98.94 š 0.30% for atenolol and 99.75 š 0.69% for lercanidipine hydrochloride), and specificity, in accordance with ICH guidelines. The method can be used for routine simultaneous analysis of atenolol and lercanidipine hydrochloride in pharmaceutical formulations.