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1 2018

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Strategia repozycjonowania, czyli nowe zastosowanie dla starych leków

Fajkis N., Kołaczkowski M., Marcinkowska M.

Wiadomości Chemiczne

2018

[Z] 72, 11-12

907--928

Drug discovery and development is associated with enormous costs, time consumption and high risk of failure. To increase the productivity, pharmaceutical companies are constantly looking for new strategies to deliver a new drug faster, with relatively lower costs. Recently, the drug repositioning has been recognized as a fruitful approach, which enables to diminish the cost and time associated with bringing a drug to the market. This review discusses the repositioning strategy, their advantages and disadvantages, along with several successful examples of drugs that have been approved for a different purpose than at the beginning of the application. The report will focus on examples of drugs that act on the central nervous system such as duloxetine, thioridazine, thalidomide and methylene blue. In addition, the article briefly describes the selective optimization of side activities of drug molecules (the SOSA approach), another highly efficient strategy, which enables to generate new biologically active compounds.