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Assessment of the Pulmonary Toxicity of Inhaled Gases and Particles With Physicochemical Methods

Sosnowski T. R., Podgórski A.

International Journal of Occupational Safety and Ergonomics

1999

Vol. 5, No. 3

431--447

Physicochemical techniques used for evaluating the pulmonary surfactant (PS) quality are discussed as methods useful in assessing toxicity of inhaled gases and particles. Two standard devices, Langmuir-Wilhelmy film balance and pulsating bubble apparatus, are presented in detail, and the measured results of interaction between sulfuric acid and 2 models of PS material are analyzed. The evident decrease in surface activity of the pulmonary surfactant after its contact with the acid at concentrations approaching 0.001 M may be considered as an indicator of the adverse effect, which can result in several health problems. The presented approach can be used as a method of assessing pulmonary toxicity of any substances present in the breathing air.