Wyniki wyszukiwania - BazTech

1

Protein release from different forms of polylactide and alginate composite carriers

Morawska-Chochół Anna

Engineering of Biomaterials

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2023

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vol. 26, no. 169

2--10

EN

The development of composite biomaterials constituting both a porous scaffold for filling tissue defects (especially bone tissue) and a carrier of biologically active substances (proteins) is an innovative approach of the presented research. The paper presents the following studies of obtained composites: model protein (bovine serum albumin, BSA) release, changes in microstructure during incubation and bioactive potential in a simulated biological environment (based on scanning electron microscopy with X-ray microanalysis – SEM/EDS – and infrared spectroscopy – FTIR). Three types of composites with a poly(L-lactide) matrix PLLA were investigated. PLA fibres covered with silica-calcium sol, calcium alginate fibres and calcium alginate beads were used as modifiers of the PLA matrix and carriers of protein. Process of releasing albumin proceeded differently depending on the material and form of the carrier. In the case of calcium alginate fibres, almost all protein was released within 14 days. For the remaining materials, this amount was reached after 3 weeks. All tested composites showed bioactive potential connected with apatite precipitation during incubation in a simulated biological environment. However, coating PLA fibres with silica-calcium sol significantly increased this effect. The highest cell viability was observed for a biomaterial modified by calcium alginate beads.

2

Ładunek powierzchniowy indukowany na bioaktywnych kompozytach

Szarska S., Niemczyk S.

Inżynieria Biomateriałów

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2006

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R. 9, nr 58-60

248-250

3

Bioaktywne kompozyty gradientowe

Chłopek J., Szaraniec B., Michalska M.

Inżynieria Biomateriałów

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2006

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R. 9, nr 58-60

94-97

PL

W pracy przedstawiono wyniki badań kompozytów o osnowie z polimeru resorbowalnego PGLA modyfikowanych proszkami, takimi jak: HAp naturalny (HAp/n), HAp syntetyczny (HAp/M), bioszkło, TCP i proszek alginianowy. Kompozyty inkubowano w wodzie destylowanej i na podstawie obserwacji mikroskopowych oraz pomiarów przewodnictwa płynu oceniano ich zachowanie "in vitro". W badaniach mechanicznych określano również wytrzymałość na rozciąganie kompozytów. Uzyskane wyniki badań pozwoliły na zaprojektowanie i wykonanie kompozytów gradientowych o kontrolowanej szybkości rozpuszczania poszczególnych faz.

EN

The results are reported on investigation of composites with resorbable polimer PGLA matrix, modified with powders such as natural HAp (HApn), synthetic HAp (HApM), bioglass, TCP and alginate powder. Composites were incubated in distilled water and based on microscopic observations and measurements of conductivity of the liquid, their "in vitro" behavior has been evaluated. Tensile strengths of composites were determined in standard mechanical tests. Obtained results enabled to design and manufacture graded composites with controlled solubility of specific component phases.

4

Bioactive carbon - ceramic composites

Chłopek J.

Inżynieria Biomateriałów

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2004

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R. 7, nr 34

3-5

EN

Bioactive carbon - ceramic composites may constitute a new group of materials that combine bioactivity of calcium phosphates (HAP, TCP) or bio-glass, and the mechanical properties of carbon-carbon composites, comparable to those natural bone tissue. Both mechanical and biological properties of these composites are affected by the type and the way of introducing the bioactive particles. The presence of bioactive phases in the examined composites considerably enhances their ability of bonding with bone tissue, while their mechanical properties remain at the level typical for carbon-carbon composites. These observations create good prospects for development of multifunctional implants designated mainly for bone surgery.