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Synteza i badania oddziaływania z albuminą N,N-pdimetyloaminobenzylowej pochodnej tiosemikarbazonu i jej kompleksu z rutenem(II)

Łomzik M., Brindell M.

Chemik

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2013

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Vol. 67, nr 2

91-98

PL

Z literatury wiadomo, że niektóre tiosemikarbazony wykazują działanie antynowotworowe jako inhibitory reduktazy rybonukleotydowej, a ich koordynacja do jonów Ru może prowadzić do wzmocnienia tej reaktywności. W artykule przedstawiono syntezę tiosemikarbazonu N,N-p-dimetyloaminobenzaldehydu oraz jego kompleksu z Ru(II). Zbadano oddziaływanie otrzymanych związków z albuminą przy użyciu metod spektrofluorymetrycznych. Wykazano, że po związaniu w kompleks ligand jest mniej reaktywny w stosunku do albuminy, co rokuje nadzieje na jego lepszą biodystrybucję.

EN

Previous studies have shown that some thiosemicarbazones have antitumor activity as inhibitors of ribonucleotide reductase and their reactivity can be enhanced by coordination to Ru ion. The following paper describes the synthesis of N,N-p-dimethylaminbenzaldehyde thiosemicarbazone and its Ru(II) complex. In addition, the interaction of the obtained compounds with albumin was carried out using fluorescence spectroscopy. It has been shown that coordination of ligand to ruthenium decrease its reactivity towards albumin and therefore the better bioavailability is expected.

2

Study on the reaction of 4-allyloxybutane-1-ol with ruthenium (II) complexes

Urbala M.

Polish Journal of Chemical Technology

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2005

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Vol. 7, nr 4

48-50

EN

The allyl ether systems undergo double-bond isomerization to 1-propenyl ethers in the presence of phosphine ruthenium (II) complexes very smoothly and effectively. However, when functionally substituted allyl ether derivatives are used as the substrates, the course of the reaction of the substrate with a metal complex is substantially determined by the complexing ability of the functional group. The reaction of allyl substrates containing primary hydroxyl group (allyloxyalcohols) with phosphine ruthenium (II) complexes (i.e. [RuClH(CO)(PPh3)3], [RuCl2(PPh3)3]) has been investigated. It was found that this reaction leads selectively to either 1-propenoxy alcohols or to cyclic 2-ethyl-[1,3] acetals, depending on the complex used as a catalyst and the reaction conditions. For the model isomerization of 4-allyloxybutan-1-ol, the optimal parameters for highly selective and efficient synthesis of 4-(1-propenyloxy)butan-1-ol or 2-ethyl-[1,3]dioxepane are established.

3

The isomerization of 1,4-diallyloxybutane catalyzed by [RuClH(CO)(PPh3)3] - the effect of reaction conditions

Urbala M.

Polish Journal of Chemical Technology

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2004

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Vol. 6, nr 2

59-61

EN

The model isomerization reaction of 1,4-diallyloxybutane catalyzed by [RuClH(CO)(PPh3)3] has been studied. This reaction practically solely leads to the formation of 1-propenyl derivatives in mild and solventless reaction conditions. A mixture of isomer products, i.e. (Z,Z)-, (Z,E)-, (E,E)-l,4-di(l-propenyloxy)butanes is formed. The effect of the reaction conditions on the yield of 1-propenyl ether and the isomers contents was examined. The temperature, the catalyst concentration, the atmosphere of the reaction gas (air or inert gas) and the reaction time were changed. From the viewpoint of a minimal concentration of ruthenium pre-catalyst, the optimal parameters for the quantitative synthesis of 1-propenyl ether have been determined. Additionally, the 100%-yield reaction time was evaluated depending on the temperature and ruthenium pre-catalyst concentration.