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Electrospun Thermoplastic Polyurethane Mats Containing Naproxen– Cyclodextrin Inclusion Complex

Akduman C., Özgüney I., Kumbasar E. P. A.

Autex Research Journal

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2014

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Vol. 14, no. 4

239--246

EN

Incorporation of cyclodextrins (CDs) into electrospun nanofibrous materials can be considered as potential candidates for functional medical textile applications. Naproxen (NAP) is a type of non-steroidal anti-inflammatory drug commonly administered for the treatment of pain, inflammation and fever. Drug-inclusion complex formation with CDs is an approach to improve the aqueous solubility via molecular encapsulation of the drug within the cavity of the more soluble CD molecule. In this study, NAP or different NAP-CD inclusion complexes loaded nanofibres were successfully produced through electrospinning and characterised. The inclusion complex loaded mats exhibited significantly faster release profiles than NAP-loaded thermoplastic polyurethane (TPU) mats. Overall, NAP-inclusion complex loaded TPU electrospun nanofibres could be used as drug delivery systems for acute pain treatments since they possess a highly porous structure that can release the drug immediately.

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Cyclodextrins as drug carriers

Mianowska B., Śliwa W.

Prace Naukowe. Chemia i Ochrona Środowiska / Akademia im. Jana Długosza w Częstochowie

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2008

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Vol. 12

155-162

EN

In the paper selected examples of cyclodextrin inclusion complexeswith drugs are presented, pointing out advantages of their encapsulation.

PL

W artykule przedstawiono wybrane przykłady kompleksów inkluzyjnych cyklodekstryn z lekami, podkreślając pozytywne zmiany właściwości leków spowodowane ich kompleksowaniem.

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Kwasy żółciowe jako komponenty architektoniczne w chemii supramolekularnej

Łotowski Z.

Wiadomości Chemiczne

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2003

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[Z] 57, 11-12

1093--1132

EN

One of the most important fields in modern synthetic chemistry is the preparation of molecules which can recognize and bind others and then catalyze transformations of the bound molecules i.e. „artificial enzymes”, and the construction of systems which can reproduce themselves or otherwise store and process information at the molecular level [5 ? 8]. The above mentioned properties of these novel synthetic structures will result not only from the presence therein of the various required elements, but also from their relative arrangements in space and the three-dimensional shape of the overall assembly. In other words, spatially separated elements combine to achieve an overall effect in these structures. Hence, there will be a requirement for molecules with well-defined geometries in which conformational freedom is kept under close control. This criterion can be met by designs based on rigid frameworks. The steroid nucleus is one of the largest rigid units which is readily available. There are many steroidal compounds which might be chosen as starting materials for more elaborate frameworks. However, bile acids are the most valuable group of these compounds due to their chemically different hydroxyl groups, enantiomeric purity, unique amphiphilicity, availability and low cost. Bile acids are natural polyhydroxylated steroidal acids existing in bile as sodium salts of N-acyl derivatives of glycine and taurine. They are synthesized from cholesterol and can solubilize hydrophobic substances by the formation of micellar aggregates and thus help in the digestion of fat lipids. In this review applications of bile acids as building blocks in the synthesis of macrocyclic and also open-chained supramolecular hosts are presented.