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Photoactivated titania-based nanomaterials for potential application as cardiovascular stent coatings

Kopaczyńska M., Sobieszczańska B., Ulatowska-Jarża A., Hołowacz I., Buzalewicz I., Wasyluk Ł., Tofail S. A. M., Biały D., Wawrzyńska M., Podbielska H.

Biocybernetics and Biomedical Engineering

2014

Vol. 34, no. 3

189--197

Intravascular stenting of atherosclerotic coronary arteries is a life-saving, widely used procedure in interventional cardiology. Adverse clinical outcomes such as restenosis high-light the importance of meeting the excellent biocompatibility by cardiovascular implants. Many attempts have been made to improve the safety profile of implant surface. We for the first time developed the photoactive intravascular titania-based nanomaterials for the application as cardiovascular stent coating. Photoactive biomaterial deposited on the cardiovascular stent surface demonstrated promising features, making it an excellent substrate for endothelial cells growth and proliferation. The biocompatibility of these coatings has been compared with 316L stainless steel surfaces typically used in commercial coronary stents production. The results of the study proved that the innovative titania- based coatings have better biocompatibility characteristics than the 316L stainless steel and in regard of its antithrombotic potential provided protection against restenosis. Further-more, the titania coating supported endothelial cells attachment and proliferation, and induced prolonged plasma recalcification time in comparison with stainless steel surface. Innovative photoactive titania coating can be an important factor to prevent the process of the restenosis in the place of implantation.

Mathematical analysis of the flow over endothelial glycocalyx

Arslan N.

International Journal of Applied Mechanics and Engineering

2007

Vol. 12, no 4

1165-1171

Mathematical modeling of the flow over the glycocalyx located on the endothelial cells (EC) was investigated. Flow regions are considered as a core flow region which is the flow in the lumen of the vessel which are simiIar flow to the Poiseuille flow inside the straight pipe and the flow over the glycocalyx located on the EC which are considered as flow through the porous media. Solutions were found in both regions and also wall shear stresses (WSS) and drag forces were calculated.