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2 International Letters of Chemistry, Physics and Astronomy

2 2014

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Synthesis and characterization of fully substituted pyrimidines by using ketene dithioacetal as potent antimicrobial agent

Khunt H. R., Pipaliya P. P., Ghelani S. M., Babariya J. S., Naliapara Y. T.

International Letters of Chemistry, Physics and Astronomy

2014

Vol. 5

134--141

Various ketene dithioacetals of acetoacetanilides were reacted with guanidine nitrate in the presence of base to produce the 2-amino-4-isopropyl-6-alkoxy-N-arylpyrimidine-5-carboxamide derivatives with good yields. All the synthesized compounds were characterized by mass, NMR and IR and also evaluated for antimicrobial activity against five different bacterial and fungal strains. The compounds 4i, 4k and 4l has found comparatively good active against all the bacterial strains.

Synthesis and antimicrobal activities of some novel triazolo[1,5-a]pyrimidine derivatives

Gami S. P., Vilapara K. V., Khunt H. R., Babariya J. S., Naliapara Y. T.

International Letters of Chemistry, Physics and Astronomy

2014

Vol. 11, iss. 2

127-134

A convenient synthesis of substituted 1,2,4-triazolo[1,5-a]pyrimidine was carried out by the reaction of various ketene dithioacetals with 5-amino 1,2,4-triazole in methanol in presence of sodium methoxide. The newly synthesized compound were characterized by 1H NMR, 13C NMR, IR, MS, elemental analysis and screened for their antimicrobial activity against various strains of bacteria and fungi.