Wyniki wyszukiwania - BazTech

Ograniczanie wyników

Znaleziono wyników: 2

Liczba wyników na stronie

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych: isoxazole

Sortuj według:

Ogranicz wyniki do:

Synthesis and Biological Screening of 3-Aryl-5-[(4′- difluoromethoxy)(3′-hydroxy)phenyl]-4,5-dihydro isoxazole

Bhadani V. N., Purohit H. D., Purohit D. M.

International Letters of Chemistry, Physics and Astronomy

2015

Vol. 47

133--138

Isoxazoline derivatives shows various types of therapeutic activities like antimicrobial[1], antiinflammatory[ 2], anticonvulsant[3], Hypoglycemic[4] etc. getting to synthesized in view of 3-Aryl-5[(4′-difluoromethoxy)(3′-hydroxy)phenyl]-4,5-dihydro isoxazole (4a-4i) have been synthesized. All the newly synthesized compounds were screened for their antibacterial activity against S. aureus, M. luteus (Gram-positive bacteria), E. coli, S. thyphi (Gram-negative bacteria) and antifungal activity against Candida albicans (Fungi). The biological activities (MIC) of the synthesized compounds were compared with known standard drugs.

Novel Synthesis of 3-Methylisoxazolo[5,4-e][1,2,4]triazepin-4-ones

Ryng S., Zimecki M., Mączyński M., Głowiak T.

Polish Journal of Chemistry

2009

Vol. 83, nr 11

1967-1976

A convenient and general method for the preparation of new 7-substituted 3-methyl - isoxazolo[5,4-e][1,2,4]triazepin-4-ones from 5-amino-3-methylisoxazole-4-carboxylic acid methylhydrazide and carbonyl compounds is described. The synthesized compounds exhibited immunosuppressive properties in the murine humoral immune response in vivo and the proliferative response of mouse splenocytes to mitogens. The X-ray structure of a representative compound is reported.