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Preparation and evaluation of a [66Ga]gallium chitosan complex in fibrosarcoma bearing animal models

Pourjavadi A., Akhlaghi M., Jalilian A. R.

Nukleonika

2011

Vol. 56, No. 1

35-40

[66Ga]gallium chitosan complex was prepared with a high radiochemical purity (greater than 99%) in dilute acetic acid solution. The radiochemical purity of [66Ga]gallium chitosan complex was checked by using paper chromatography technique. The prepared complex solution was injected intratumoral to fibrosarcoma-bearing mice and the leakage of radioactivity from injection site was investigated. Approximately, 85.4% of the injected dose was retained in the injection site 54 h after injection and most of the leaked radioactivity was accumulated in the blood, liver (0.5%) and lung (6.5%).