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Content available Robustness of closed-loop glucose control systems
EN
The main purpose of this work is to provide an extensive, simulation-based comparison of robustness of PID and MPC algorithms in control of blood glucose levels in patients with type 1 diabetes and thus answer the question of their safety. Cohort testing, with 1000 simulated, randomized patients allowed to analyze specific control quality indicators, such as number of hypoglycemic events, and length of hypo- and hyperglycemia periods. Results show that both algorithms provide a reasonable safety level, taking into account natural changes of patients’ physiological parameters. At the same time, we point out drawbacks of each solution, as well as general problems arising in close-loop control of blood glucose level.
2
Content available remote Analysis of data generated by insulin pump using LabVIEW environment
EN
Diabetes mellitus is a group of metabolic diseases characterized by impaired insulin secretion or action affecting around 200 million people worldwide. Type 1 diabetes makes up 10% of all diabetes cases. Currently, the most physiological way of insulin delivery involves the use of an insulin pump, which administers insulin in a continuous manner. During an outpatient visit insulin pump data are read and analyzed to optimize treatment and improve patients metabolic control. There are commercial software companies producing insulin pumps which present data in a report format. The aim of this project was to write a program in a LabVIEW environment which would analyze the insulin pump data. The program includes structured bookmarks, statistics on glucose (different systems of measurement), insulin, nutritional information, uses advanced tools in the pump, and presents the entire recorded history of pump data (commercial version statistics use only two week time intervals). Implemented as an innovative feature that compares the blood glucose meter to indicate the continuous glucose monitoring system. The software built for this purpose can be used in diabetes clinics to analyze insulin pump data and to research on the application of new diabetes technology. The current version can be treated as a foundation for possible further expansion of the program functionality.
EN
This paper explains what insulin pump is and outlines basic requirements for such device. The material presented in this paper is an attempt to collect actual knowledge about closed loop insulin delivery systems. From scientific point of view we are going to propose the closed loop insulin-dispensing device with control built on the base of predictive neural network system. The blocks of such systems are listed, and main problems to overcome are defined.
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