PL
 |
EN
Preferencje help
Polish version English version Język
Widoczny [Schowaj] Abstrakt
Liczba wyników

Znaleziono wyników: 8

Liczba wyników na stronie
first rewind previous Strona / 1 next fast forward last
Wyniki wyszukiwania
Wyszukiwano:
w słowach kluczowych:  inclusion complex
help Sortuj według:

help Ogranicz wyniki do:
first rewind previous Strona / 1 next fast forward last
1
Content available Encapsulation of l-menthol in hydroxypropyl-β-cyclodextrin and release characteristics of the inclusion complex
Zhu G., Xiao Z., Zhu G., Zhou R., Niu Y.
Polish Journal of Chemical Technology
|
2016
|
Vol. 18, nr 3
110--116
EN
l-menthol has been widely used in flavour, food and pharmaceuticals. Because of its high volatility and whisker growth, l-menthol-hydroxypropyl-β-cyclodextrin inclusion complex was produced to improve shelf-life, provide protection, and enhance the stability of l-menthol. The inclusion complex was characterized by Fourier transform infrared spectroscopy, X-ray diffraction. The results show that l-menthol was successfully encapsulated in hydroxypropyl-β-cyclodextrin. l-menthol loading capacity is about 8.44%. Geometries and binding energies of l-menthol-hydroxypropyl-β-cyclodextrin inclusion complexes were investigated using molecular mechanics calculations. The shape and orientation of the most stable complex, and the minimum binding energy were determined. L-menthol release from complex was determined by thermogravimetric analysis. Two l-menthol release rate peaks were observed at 69.3 and 279.1°C. The l-menthol release reaction order, release activation energy and the preexponential factor were obtained.
2
Content available remote Electrospun Thermoplastic Polyurethane Mats Containing Naproxen– Cyclodextrin Inclusion Complex
Akduman C., Özgüney I., Kumbasar E. P. A.
Autex Research Journal
|
2014
|
Vol. 14, no. 4
239--246
EN
Incorporation of cyclodextrins (CDs) into electrospun nanofibrous materials can be considered as potential candidates for functional medical textile applications. Naproxen (NAP) is a type of non-steroidal anti-inflammatory drug commonly administered for the treatment of pain, inflammation and fever. Drug-inclusion complex formation with CDs is an approach to improve the aqueous solubility via molecular encapsulation of the drug within the cavity of the more soluble CD molecule. In this study, NAP or different NAP-CD inclusion complexes loaded nanofibres were successfully produced through electrospinning and characterised. The inclusion complex loaded mats exhibited significantly faster release profiles than NAP-loaded thermoplastic polyurethane (TPU) mats. Overall, NAP-inclusion complex loaded TPU electrospun nanofibres could be used as drug delivery systems for acute pain treatments since they possess a highly porous structure that can release the drug immediately.
3
Content available remote Cyclodextrins as drug carriers
Mianowska B., Śliwa W.
Prace Naukowe. Chemia i Ochrona Środowiska / Akademia im. Jana Długosza w Częstochowie
|
2008
|
Vol. 12
155-162
EN
In the paper selected examples of cyclodextrin inclusion complexeswith drugs are presented, pointing out advantages of their encapsulation.
PL
W artykule przedstawiono wybrane przykłady kompleksów inkluzyjnych cyklodekstryn z lekami, podkreślając pozytywne zmiany właściwości leków spowodowane ich kompleksowaniem.
4
Determination of Thermodynamic and Kinetic Parameters of Inclusion Comnplex Formation of 2-Mercaptobenzothiazole with beta-Cyclodextrin
Zha F., Lu R.
Polish Journal of Chemistry
|
2005
|
Vol. 79 / nr 9
1461-1467
EN
The inclusion of 2-mercaptobenzothiazole by beta-cyclodextrin was studied by spectrophotometry. The absorbance of inclusion complex decreased when _-cyclodextrin was dissolved in water and the complex was diluted with ethanol. The same result was obtained by using water as the solvent and diluent. The absorbance decrease in ethanol was greater than that in water. The absorbance increased with the increase of the content of _-cyclodextrin when DMSO was used both as the solvent and diluent. Although the absorbance of the complex was higher than that of the guest when beta-cyclodextrin was dissolved inDMSOand inclusion complex was diluted with water, the absorption decreased when the concentration of beta-cyclodextrin was increased. Stability constants of the inclusion complex in different solvents changed in the order KDMSO < KH2O < KEtOH. Further studies showed that formation of the inclusion complex was spontaneous and exothermic. Thermodynamic parameters and the rate constants of the inclusion reaction were determined.
5
Structure, Thermal Stability and Water Solubility of (Tanshinone II-A)/((beta-Cyclodextrin) Inclusions Complex
Yang Sh., Hu M., Shen Y., Ma X.
Polish Journal of Chemistry
|
2004
|
Vol. 78 / nr 1
53-61
EN
The structure of the inclusion complex of tanshinone II-A and _-cyclodextrin formed under microwave irradiation was studied by the UV, IR, and NMR spectroscopy. The association constant of the complex in water is 210 M-1, as determined from the double reciprocal curve by UV spectroscopy. The enhanced water solubility of the complex was found. Thermal studies proved the increased thermal stability of the inclusion complex.
6
Study of the Inclusion Complexes of Catecholamines with beta-Cyclodextrin by Cyclic Voltammetry
Gao Z., Wen X. -L., Li H. -L.
Polish Journal of Chemistry
|
2002
|
Vol. 76 / nr 7
1001-1007
EN
The inclusion complexes of catecholamines (dopamine, DA, and adrenaline, AD) with beta-cyclodextrin (beta-CD) have been studied by cyclic voltammetry (CV) using glassy carbon electrode (GCE) for expanding the potential window. The variations of peak potential and peak current were observed on cyclic voltammograms, when the electroactive guest molecules, DA and AD are complexed with beta-CD. Dissociation constants of cyclodextrin inclusion complexes have been calculated. The experimental results indicate that bothDAandADcan form a 1:1 inclusion complexes with beta-CD in aqueous solutions. It was observed that the light and oxygen sensitivity of the inclusion complex is much lower than those of the free catecholamines, which can be used to improve their storage and handling, and also widen their applications in pharmaceutical industry. Furthermore, it was found that their electrochemical oxidation in the aqueous solutions could be inhibited by beat-CD.
7
Investigation of (Beta-Cyclodextrin)-Lappaconitine Inclusion Complex
Yan X
Polish Journal of Chemistry
|
2001
|
Vol. 75, nr 9
1297-1302
EN
The structure of the inclusion complex of Lappaconitine (Lap) and _-cyclodextrin (_-CD) was studied by theUV, infrared, andNMRspectroscopy, as well as X-ray powder diffractometry. The stability constant of the complex in water is 275 M-1, determined from the straight line portion of the phase-solubility diagram.
8
Electrochemical and UV-VIS Spectroscopic Study of Inclusion of Azobenzene Derivative by B-Cyclodextrin
Wang Z., Zhang H., Li H.
Polish Journal of Chemistry
|
1999
|
Vol. 73, nr 11
1855-1861
EN
Cyclic voltammetry results showed that the cathodic peak potential for MCA was shifted towards negative values and the peak current was decreased, when the B-CD concentration was increased. MCA is adsorbed strongly on the glassy carbon electrode.The surface concentration of MCA was determined by chronocoulometry.
first rewind previous Strona / 1 next fast forward last
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.