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  1. 4 Engineering of Biomaterials
  2. 2 Inżynieria Biomateriałów
  3. 1 Acta of Bioengineering and Biomechanics
  4. 1 Advances in Materials Science
  5. 1 Analityka : nauka i praktyka
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  1. 2 Budner B.
  2. 2 Chłopek J.
  3. 2 Cieślik M.
  4. 2 Douglas T. E. L.
  5. 2 Menaszek E.
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  1. 2 2022
  2. 1 2018
  3. 1 2016
  4. 1 2013
  5. 3 2012
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1
Content available Analityka antybiotyków β-laktamowych w układzie in silico, in vitro oraz in vivo
Janiszewska Daria, Szultka-Młyńska Małgorzata, Buszewski Bogusław
Wiadomości Chemiczne
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2022
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[Z] 76, 3-4
109--127
EN
Drug analysis necessitates introducing selective methods of detection and enriching the substances present in biomaterial at low concentration levels (trace analysis). Moreover, there is a continuous demand for increase in the quality of drugs that are being developed, which in turn enforces the development of analytical techniques of increasing sensitivity and accuracy with the applicationof combined separation techniques. Thus the premise of this review is to comparethe in vitro metabolic pathways of antibiotic drugs in model conditions such as in the presence of different microsomal fraction enzymes and with the applicationof electrochemical stimulation of metabolic transformations, as well as to the collected data with the results of in vivo experiments.
2
Content available remote Characterization of a commercial EPID-based in-vivo dosimetry and its feasibility and implementation for treatment verification in Malaysia
Radzi Yasmin Md, Rahman Azhar Abdul, Noor Rizan Noor Naslinda, Oskhahar Nur Nabilah, Abd Latif Nur Fatin Fariha
Polish Journal of Medical Physics and Engineering
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2022
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Vol. 28, Iss. 4
215--221
EN
Introduction: In vivo dosimetry verification is currently a necessity in radiotherapy centres in Europe countries as one of the tools for patient-specific QA, and now its demand is currently rising in developed countries, such as Malaysia. The aim of this study is to characterize commercial EPID-based dosimetry and its implementation for radiotherapy treatment verification in Malaysia. Materials and Methods: In this work, the sensitivity and performance of a commercially available in vivo dosimetry system, EPIgray® (DOSIsoft, Cachan, France), were qualitatively evaluated prior to its use at our centre. EPIgray response to dose linearity, field size, off-axis, position, and angle dependency tests were performed against TPS calculated dose for 6 MV and 10 MV photon beams. Relative deviations of the total dose were evaluated at isocentre and different depths in the water. EPIgray measured dose was validated by using IMRT and VMAT prostate plan. All calculation points were at the beam isocentre and at points suggested by TG-119 with accepted tolerance of ±10% dose threshold. Results: EPIgray reported good agreement for linearity, field size, off-axis, and position dependency with TPS dose, being within 5% tolerance for both energy ranges. The average deviation was less than ±2% and ±7% in 6 MV and 10 MV photon beams, respectively, for the angle dependency test. A clinical evaluation performed for the IMRT prostate plan gave average agreement within ±3% at the plan isocentre for both energies. While for the VMAT plan, 95% and 100% of all points created lie below ±5% for 6 MV and 10 MV photon beam energy, respectively. Conclusion: In summary, based on the results of preliminary characterization, EPID-based dosimetry is believed as an important tool and beneficial to be implemented for IMRT/VMAT plans verification in Malaysia, especially for in vivo verification, alongside existing pre-treatment verification.
3
Nanocząstki złota jako potencjalne metalo-nanomateriały teranostyczne - właściwości oraz analiza za pomocą ICP-MS
Matczuk M., Kur A., Legat J., Ruzik L.
Laboratorium - Przegląd Ogólnopolski
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2018
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nr 2
26--33
PL
Nanocząstki złota to jedne z najintensywniej testowanych metalonanomateriałów o potencjalnych właściwościach teranostycznych. Zarówno łatwość ich syntezy, unikalne właściwości fizyczne, jak i rozbudowana chemia powierzchni są powodami tak intensywnego nimi zainteresowania w materii wczesnego wykrywania i efektywnego leczenia nowotworu. Jednak by nanocząstki mogły być w przyszłości zakwalifikowane do badań klinicznych, niezbędny jest szereg testów in vitro i in vivo opisujących ich transport i metabolizm. Jedną z najczęściej stosowanych w tym celu technik jest ICP-MS.
EN
Gold nanoparticles are one of the most intensively tested metalo-nanomaterials in terms of their potential theranostic application. The reasons of such intensive attention paid to them, related to the early diagnosis and effective theraphy of cancer, are the simplicity of their synthesis, unique physical properties and the extensive surface chemistry. However, in order to qualify gold nanoparticles to clinical trials, it is necessary to carry out in vitro and in vivo tests describing their transportation and metabolic processes. One of the most frequently used technique adopted to fulfill this purpose is ICP-MS.
4
Zastosowanie LA ICP MS do ilościowego zobrazowania rozmieszczenia in vivo pierwiastków w tkankach roślin grochu
Hanć A., Barałkiewicz D., Piechalak A., Tomaszewska B.
Analityka : nauka i praktyka
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2016
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nr 1
13--16
PL
Do wyzwań stawianych LA ICP MS w analityce chemicznej, poza określeniem in vivo rozmieszczenia pierwiastków w próbkach roślin czy też poznaniem ich szlaków migracyjnych, należy oznaczenie zawartości pierwiastków toksycznych i pierwiastków fizjologicznych w tkankach roślin.
5
Content available Evaluation of nutrients bioavailability from fertilizers in in vivo tests
Tuhy Ł., Samoraj M., Chojnacka K.
Interdisciplinary Journal of Engineering Sciences
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2013
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Vol. 1, no. 1
10--13
EN
Bioavailability of nutrients is crucial in obtaining high crop yields and influences the possible pollution of groundwater. The paper presents in vivo methods (seed testing, pot trials, field trials) of the evaluation of micronutrients bioavailability from fertilizers which enable selection of the most efficient way of micronutrient fertilization by determination of bioavailability of micronutrients, plant height and crop yields.
PL
Biodostępność składników odżywczych dla roślin jest istotna z punktu widzenia osiągniętych plonów oraz możliwego wpływu na zanieczyszczenie wód gruntowych jonami metali dostarczanych roślinom wraz z nawozem. Metody określania biodostępności mikroelementów in vivo (testy kiełkowania, doświadczenia wazonowe oraz polowe) umożliwiają wybór nawozu mikroelementowego charakteryzującego się najwyższą wydajnością nawożenia na podstawie uzyskanych wyników biodostępności oraz plonowania roślin. Niewątpliwą zaletą badań in vivo jest łatwość przeniesienia otrzymanych wyników na warunki środowiskowe. Niestety, czas trwania doświadczeń oraz ich wysoki koszt (przede wszystkim testów polowych) sprawiają, że wciąż poszukuje się alternatywnych rozwiązań w postaci testów in vitro. Istnieje jednak konieczność potwierdzenia rezultatów otrzymanych w badaniach in vitro badaniami in vivo.
6
Content available Influence of thin films of bioglass and hydroxyapatite mixture deposited by PLD method on bioactivity of foam titanium implants
Mróz W., Budner B., Załęczny R., Bombalska A., Niedzielski K., Łączka M., Ślósarczyk A., Cholewa-Kowalska K., Douglas T. E. L., Schwarze D.
Engineering of Biomaterials
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2012
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Vol. 15, no. 116-117 spec. iss.
148
EN
The introduction of different bioelements into the structure of hydroxyapatite exerts a positive influence on the growth of new bone tissue. One such useful bioelement is silica, which possesses antibacterial properties and also acts as a factor regulating bone mineralization through stimulation of DNA to synthesize osteoblasts. Results of investigations into integration of foam titanium implants (FTI), with rabbit bone are presented. Two groups of implants were investigated: clean titanium implants produced by selective laser melting and FTI coated with a thin film of hydroxyapatite (HA) mixed with 10 wt. % of bioglass (BG) of A2 type (CaO- P2P-SiO2). Analysis of histopathology of implants' integration with bone were performed by staining using the triple chromatographic method of Masson - Goldner, planimetric analysis using the Kruskal - Wallis test, an ANOVA test and microtomography. Application of layers of the type HA+GH showed superior integration with bone than uncoated titanium implants.
7
Content available In vivo application of foam titanium implants with magnesium-doped octacalcium phosphate and hydroxyapatite thin films deposited by PLD method
Mróz W., Budner B., Załęczny R., Prokopiuk A., Niedzielski K., Ślósarczyk A., Douglas T. E. L., Scharze D.
Engineering of Biomaterials
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2012
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Vol. 15, no. 116-117 spec. iss.
141
EN
Results of investigations into integration of foam titanium implants (FTI), with rabbit bone are presented. Three groups of implants were examined: clean titanium implants produced by selective laser melting, FTI coated with a thin film of octacalcium phosphate (OCP), doped with 0.6 weight percent of Mg, deposited by pulsed laser deposition (PLD), and FTI with hydroxyapatite (HA) doped with 0.6 wt.% of Mg. Analysis of histopathology of implants' integration with bone were performed by staining using the triple chromatographic method of Masson - Goldner, pla- nimetric analysis using the Kruskal - Wallis test, an ANOVA test and microtomography. The best results were obtained for implants coated with HA, followed by those coated with OCP. Implants from these two groups showed superior integration with bone than uncoated titanium implants.
8
Content available In vitro studies of different types of carbon nanotubes deposited on PTFE membrane
Frączek-Szczypta A., Menaszek E., Miranowicz M., Błażewicz S.
Engineering of Biomaterials
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2012
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Vol. 15, no. 116-117 spec. iss.
153--154
9
Content available remote Impact of some external factors on the values of mechanical parameters determined in tests on bone tissue
Nikodem A., Ścigała K.
Acta of Bioengineering and Biomechanics
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2010
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Vol. 12, no. 3
85-93
EN
The knowledge of the mechanical characteristics of bone structures is a prerequisite for theoretical, numerical, and experimental analyses describing the functioning of bone, which is a living organ. The description of the mechanical properties of bone tissue, such as conventional Young’s modulus or strength, will enable the assessment of the degree of tissue degeneration through a comparison of the material properties of the examined bones to the properties determined for physiologically normal bones. However, the mechanical parameters published by different research centres often differ from each other by up to several hundred percent. These discrepancies arise primarily from the differences in the research methodology applied, and thus from many additional factors having a direct impact on the values of the mechanical parameters obtained in experimental tests. Therefore, in order to standardize and improve the interpretation of the results of measurements, we should develop universal criteria for the measuring conditions and quantify the impact of the factors being related to sample and measurements on the values obtained. In this paper, the authors present the dependence of some factors, i.e. the site and direction of sample excision as well as the rate and type of loading, on the values of the mechanical parameters. Those values were determined in experimental tests and the additional correlation coefficients proposed enabled an easier comparison of the results obtained with the values presented in the literature.
10
Content available Badania powierzchni panewki stawu biodrowego po dziesięciu latach kontaktu z organizmem
Cieślik M., Mlekodaj K., Janus A. M., Łojewski T., Engvall K., Kotarba A.
Engineering of Biomaterials
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2009
|
Vol. 12, no. 89-91
54--56
11
Content available Skutki biologiczne ekspozycji na pola elektromagnetyczne– badania eksperymentalne
Wiaderkiewicz R.
Podstawy i Metody Oceny Środowiska Pracy
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2008
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Nr 4 (58)
47--65
PL
Prezentowana praca jest przeglądem badań eksperymentalnych nad wpływem pól elektromagnetycznych na procesy biologiczne przebiegające w organizmach żywych. Przedstawiono metody stosowane do oceny oddziaływania pól elektromagnetycznych na poziomie komórkowym oraz dokonano analizy otrzymanych za ich pomocą wyników.
EN
The paper is a review of experimental studies on the effects of electromagnetic fields on biological processes in living organisms. It presents the methods used and analyses the results obtained with different experimental approaches.
12
Content available remote Measurement by load cells of impact force which a human body receivesby external force
Ito Y., Nemoto T., Ogura T., Yamasita H., Yanai S., Matsuura H.
Journal of Achievements in Materials and Manufacturing Engineering
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2008
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Vol. 28, nr 1
39-42
EN
Purpose: By development of a robotics technique, the assisted living instruments which have intelligent functions are being developed. As a result, there is a possibility that the accident to which the assisted living instrument under actuation contacts a human body may occur. The purpose of this research is for the impact force measurement system which with load cells to build, and to evaluate performance. Design/methodology/approach: The impact force measurement system was built by load cells and a data logger. Evaluation of the performance of the system was carried out to static loads and dynamic loads. Findings: By covering the sensor part of load cells with shock absorbing material, it turned out that it is possible to measure impact load simple. Moreover, as a result of comparing the characteristic of shock absorbing material, it became clear that the impact-absorbing characteristic of cell sponge and organism soft tissue is in agreement. Research limitations/implications: This research estimated the impact-absorbing characteristic of organism soft tissue for the skin, fat, muscles, etc. as a complex. Practical implications: This paper cleared that the load which a bone receives by dynamic external force can be easily measured by load cells. Originality/value: The objective of this research project was to develop the system by which impact force is measured and evaluated based on the damage which a human body receives. And we were able to complete the prototype.
13
Content available remote Assessment of the lactide-co-glycolide and its composite degradation velocity under in vitro and in vivo conditions
Chłopek J., Morawska-Chochół A.
Advances in Materials Science
|
2007
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Vol. 7, nr 2(12)
86-91
EN
The aim of this work was the analysis of the modifying phase effect (hydroxyapatite particles and carbon fibres) and environment role (in vitro and in vivo) on mechanism and velocity of the resorption process of polylactide-co-glycolide (PGLA). Resorption time of samples incubated in simulated biological environment was determined on the basis of pH changes of the Ringer's solution. Scanning electron microscopy and infrared spectroscopy were applied for the estimation of the resorption degree of the polymer. It was observed that carbon fibres addition accelerates distinctly in vitro matrix degradation, whereas in the natural biological environment fibres reduce this time. In the case of composite with hydroxyapatite nanoparticles the in vitro processes are complex and difficult to explain. In this case simultaneous occurrence of three processes is possible: polymer resorption, HAP precipitation and dissolution. In the biological environment reduce polymer resorption time is no-ticeable.
14
Analiza wskaźników oceny struktury kości in vitro i in vivo
Mazurkiewicz A., Topoliński T.
Przegląd Mechaniczny
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2005
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nr 6
40-44
PL
W pracy przedstawiono wybrane wskaźniki oceny struktury kości wykorzystywane w ocenie ich wytrzymałości in vivo, których wartości ustalane są w badaniach in vivo lub in vitro. Celem pracy była także ocena możliwości wykorzystania i przydatności pomiaru równomierności rozkładu gęstości (a więc i równomierności budowy strukturalnej) jako wskaźnika służącego do wstępnego określania wytrzymałości posiadanych preparatów kostnych przed próbami wytrzymałościowymi. Stwierdzono, że równomierność rozkładu gęstości w próbce jest wyższa dla kości koksartrycznych niż osteoporotycznych przy podobnej gęstości średniej struktury, a uzyskane rozkłady dla preparatów o porównywalnych gęstościach prześwietleniowych są istotnie różne.
EN
Selected indicators of bone structure evaluation have been presented. These indicators are used in bone strength evaluation in vivo (values of indicators are established in vitro or in vivo). The aim of the work was also estimation of utilization possibility and suitability of uniformity of density distribution uniformity measurements (uniformity of bone struc-ture) as an indicator for preliminary determination of bone samples strength. It was found that uniformity of density distribution in the sample is higher for coxarthritic bones than for osteoporotic ones with the same average density. Distribution of the uniformity for samples with comparable densities was essentially different.
15
Content available Wpływ wielkości porów resorbowalnych gąbek PGLA na odpowiedź tkankową : badania in vivo
Menaszek E., Pamuła E.
Inżynieria Biomateriałów
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2005
|
R. 8, nr 47-53
221--223
16
Content available Degradacja kompozytów z polimerów resorbowalnych w warunkach in vivo
Chłopek J., Morawska-Chochół A., Adwent M., Cieślik-Bielecka A., Cieślik M.
Inżynieria Biomateriałów
|
2005
|
R. 8, nr 47-53
197--202
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