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Hematopoietic stem cell based therapy of immunosuppressive viral infection — Numerical simulations

Korpusik A.

Biocybernetics and Biomedical Engineering

2014

Vol. 34, no. 2

125--131

In the light of recent advantages in stem cell research and gene based therapies of viral infections, we present a numerical experiment referring to hematopoietic stem cell based therapy of immunosuppressive viral infection. We use a variation of basic mathematical model for impairment of help to simulate immune impairing infection. Next, we increase virus-specific CTL production (as in therapy) in different stages of infection. Obtained results are analyzed and compared with results from recent in vivo experiment.

Search for New Synthetic Immunosuppressants. Antamanide Analogues Containing the Tetrazole Ring as a cis-Peptide Bond Mimetic

Zubrzak P., Kaczmarek K., Kowalski M. L., Szkudlińska B., Zabrocki J.

Polish Journal of Chemistry

2001

Vol. 75, nr 12

1869-1876

Linear and cyclic antamanide (ANT) analogues with dipeptide segments Pro2-Pro3, Pro7-Pro8 and both of them replaced by their tetrazole analogue Pro-psi[CN4]-Ala, respectively, have been synthesized by SPPS method and cyclization with TBTU reagent. The peptides were examined for their immunosuppressive activity in a lymphocyte proliferation test (LPT).