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Synthesis of 2,6-Diaminopimelic Acid (DAP) and Its Analogues

Dzierzbicka K.

Polish Journal of Chemistry

2007

Vol. 81, nr 4

455-473

This article reviews synthesis of 2,6-diaminopimelic acid, an important amino acid biosynthesized by bacteria and higher plants. Anumber of peptidoglycan fragments containing the diaminopimelic acid (DAP) residue exhibit antitumor and/or immunostimulant activity. DAP is a versatile building block of many natural and synthetic compounds with a number of potentialmedicinal applications. The synthesis of immunostimulants FK-156 and FK-565 is also presented.