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EN
Using physiologically active, complex, polyfunctional, multicomponent (nano) systems – (nano) chips in the pre-sowing soya treatment (nano) technology allows precise seeding; enhancing field seed germination; reducing plant morbidity rate considerably or even deleting disease incidents; increasing plant adaptability to unfavorable environmental conditions; expanding crop yield; improving products quality by not using toxic chemical means of plant protection; intensifying competitive ability of agricultural products as well as assuring environmental safety in crop cultivation regions.
EN
Synthesis of new conjugates of muramyl dipeptide (MDP) and nor-muramyl dipeptide (nor-MDP) with retro-tuftsin derivatives is presented. The corresponding protected retro-tuftsin derivatives were also synthesized. The synthesis of a greater number of conjugates will enable structure-activity relation ship studies.
EN
The synthesis of retro-tuftsin analogue of sequence Arg-Pro-Lys-ThrOMe (Scheme 1) and it's conjugates containing MDP (muramyl dipeptide) or nor-MDP (nor-muramyl dipeptide) (Scheme 2) are described.
EN
Muramyl peptides are fragments of peptidoglycan from the cell walls of bacteria. This article concerns muramyl peptides, and new analogues which are considered as prodrugs. Their synthesis and biological activity are also presented.
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