Wyniki wyszukiwania - BazTech

1

Jachimowicz-Rogowska Karolina, Winiarska-Mieczan Anna, Chmielowiec-Korzeniowska Anna, Tymczyna Leszek, Czernecki Tomasz, Banach Marcin, Potrzebski Daniel

Przemysł Chemiczny

|

2023

|

T. 102, nr 3

277--286

PL

Dokonano przeglądu dostępnej literatury dotyczącej β-glukanów pod kątem ich prozdrowotnego działania na organizm człowieka. Przedstawiono główne źródła pozyskiwania β-glukanów oraz zróżnicowano ich strukturę chemiczną w zależności od pochodzenia. Aktualne wyniki badań potwierdzają, że β-glukany wykazują działanie obniżające stężenie cholesterolu całkowitego, frakcji nie-HDL i LDL w surowicy krwi, korzystnie wpływają na metabolizm glukozy oraz mają właściwości antyoksydacyjne, przeciwzapalne, immunostymulujące, przeciwnowotworowe i prebiotyczne.

EN

A review, with 50 refs., of β-glucans used as food components. Main sources of β-glucans, their chem. structure, viscosity, rheol. properties, texture and sensory characteristics were presented. In particular, their effects on concns. of cholesterol, non-HDL and LDL fractions in blood serum and on glucose metabolism as well as their antioxidant, immunostimulant, anti-cancer and prebiotic properties were taken into consideration.

2

Medical significance of nematodes

Nieradko-Iwanicka Barbara, Chodun-Wróblewska Wiktoria

Polish Hyperbaric Research

|

2023

|

nr 3(84)

41--56

EN

Nematodes are invertebrates that can cause parasitic diseases in humans, animals and plants. These organisms also participate in the decomposition of dead remains of organisms. In recent years, new reports have appeared on the possibility of using intentional nematode infections in the treatment of autoimmune and neurological diseases. The aim of this work is to summarize information about nematodes pathogenic to humans and the possibilities of therapeutic use of some nematodes. 36 original and review publications from 2008-2022 were analyzed. Information was collected on 13 diseases caused by parasitic nematodes in humans (reservoir, routes of infection, susceptible organisms, symptoms of infection). Current publications on trials of using Trichuris suis eggs (TSO) in animal models, in healthy humans and in people with inflammatory bowel diseases (IBD) or autism spectrum disorder (ASD) or multiple sclerosis (MS) are summarized. Clinical improvement was observed in some of the subjects. However, researchers draw attention to the depletion of the biodiversity of the host's intestinal microbiota in the presence of TSO. Conclusions: The results of research on the therapeutic use of TSO remain inconclusive. There are many more diseases caused by parasitic nematodes in humans than there are documented therapeutic effects of TSOs. Exposure to parasitic nematodes’ eggs (especially Toxocara canis and Toxocara cati) is still very common.

3

Curcumin delivery systems as dressing components for the treatment of diabetic foot ulcers: test on macrophages polarization

Wójcik Karolina, Kusibab Anna, Sousa Ana Beatriz, Barbosa Judite Novais, Pamuła Elżbieta

Engineering of Biomaterials

|

2023

|

vol. 26, no. 168

15--24

EN

The natural wound healing process consists of four basic phases: homeostasis, inflammation, proliferation, and remodelling. Macrophages play an important role in the body’s response to biomaterials, as they are modulators of the wound healing process and can polarize into different phenotypes capable of inducing both deleterious and beneficial effects on tissue repair. Curcumin (CU) is known for its anti-inflammatory properties and has the potential to treat diabetic foot ulcers, but it should be delivered to wounds in a controlled manner. In this study, the encapsulation of curcumin in polymeric microparticles based on poly(sebacic anhydride) (PSA) was developed using an emulsification method. PSA-based microparticles containing different concentrations of CU were obtained: 0% weight (wt). CU (unloaded microparticles), 5, 10, and 20 wt% CU. CU encapsulation efficiency and loading were determined using a fluorescence-based calibration curve method and semi-quantitative Fourier-transform infrared spectroscopy (FTIR) analysis. The potential cytotoxicity of the obtained biomaterials in contact with primary human macrophages and their susceptibility to polarization from the M1 (pro-inflammatory) phenotype to the M2 (antiinflammatory) phenotype were evaluated. The morphology of cells cultured in contact with polymeric microparticles was evaluated using phalloidin red and 4′,6-diamidino2-phenylindole (DAPI) staining. Macrophage phenotype was assessed using flow cytometry. The obtained biomaterials showed no cytotoxic effect on primary human macrophages. Flow cytometry studies showed enhanced polarization of macrophages into anti-inflammatory M2 phenotype when exposed to microparticles loaded with CU and CU powder as compared to unloaded microparticles

4

Leczenie tlenoterapią hiperbaryczną (HBOT) jako opcja terapeutyczna dla chorych na atopowe zapalenie skóry (AZS) – doświadczenia własne i przegląd piśmiennictwa

Olszański R., Konarski M., Siermontowski P.

Polish Hyperbaric Research

|

2017

|

nr 3(60)

27--36

PL

W pracy przedstawiono wyniki leczenia dziesięciu pacjentow chorujących na ciężką postać atopowego zapalenia skory (AZS), nie reagujących na typową farmakoterapię, ktorych poddano leczeniu tlenoterapią hiperbaryczną (HBOT). U każdego z pacjentow zastosowano 10 ekspozycji tlenowych przy pO2 2,5 ATA (~250 kPa) i czasie trwania 60 min. Na czas realizacji procedur hiperbarycznych u wszystkich chorych odstawiono leczenie ogolne, utrzymując typowe postępowanie miejscowe. W grupie badanej przeprowadzano oceną kliniczną, a także określano poziom immunoglobulin: IgA, IgG, IgM i IgE oraz składowych C3 i C4 dopełniacza. U wszystkich pacjentow uzyskano poprawę kliniczną, a także stwierdzono zmniejszenie się poziomu immunoglobuliny IgE i składowej dopełniacza C3 po zakończeniu cyklu ekspozycji. Biorąc pod uwagę obserwacje własne i dane z piśmiennictwa, ogolna poprawa stanu klinicznego oraz obniżenie poziomu immunoglobuliny E i składowej C3 dopełniacza po cyklu ekspozycji może świadczyć o immunomodulującym wpływie HBOT na przebieg AZS, a tlenoterapia hiperbaryczna może stanowić opcję terapeutyczną dla niektorych chorych na AZS, w szczegolności tych słabo reagujących na standardowe leczenie.

EN

The paper discusses the treatment results of ten patients with severe atopic dermatitis (AD) who did not respond to standard pharmacotherapy and underwent hyperbaric oxygen therapy (HBOT). Each patient was subject to 10 oxygen exposures at pO2 2.5 ATA (~ 250 kPa) with the duration time of 60 minutes. In the period of implementation of the hyperbaric procedures the general treatment plan was suspended for all patients while maintaining typical local treatment. Clinical evaluation was performed in the study group as well as determination of levels of immunoglobulins: IgA, IgG, IgM and IgE and C3 and C4 complement. All patients indicated clinical improvement and a decreased IgE immunoglobulin and complement C3 level upon the completion of the exposure cycle. Taking into account the authors' own observations and data from literature, an overall improvement in the clinical status and a decrease in the level of immunoglobulin E and C3 complement following a cycle of exposures may be indicative of an immunomodulating HBOT effect on AD, whereas hyperbaric oxygenation may constitute a therapeutic option for some patients with AD, especially those exhibiting a poor response to standard treatment.

5

Immunomodulacyjne właściwości mikroorganizmów

Ograczyk E., Micota B., Miszczyk E., Gajewski E., Włodarczyk M., Rudnicka K., Sadowska B.

LAB Laboratoria, Aparatura, Badania

|

2015

|

R. 20, nr 3

11--18

6

Immunomodulatory Effects of 900 MHz Magnetic Field Applied on Human Blood T Lymphocytes in vitro

Stankiewicz W., Samochocki Z., Kieliszek J., Sobiech J., Bartosiński A., Bodera P., Krawczyk A., Dąbrowski M. P.

Przegląd Elektrotechniczny

|

2011

|

R. 87, nr 12b

155--156

EN

T lymphocytes were isolated from blood samples of 15 patients suffering from atopic dermatitis and 20 healthy donors. Cell cultures were exposed to the impact of 900 MHz electromagnetic field in the special anechoic chamber. The immunomodulatory effects of 900 MHz magnetic field on T lymphocytes were observed especially on cells isolated from patients suffering from atopic dermatitis

PL

Limfocyty T zosta!y wyizolowane z krwi 20 zdrowych dawców i 15 chorych na atopowe zapalenie skóry. Hodowle komórkowe poddawane były dzia!aniu pola elektromagnetycznego o częstotliwości 900 MHz w specjalnej komorze bezechowej. Wyniki wskazują na korzystne immunomodulacyjne działanie 900 MHz PEM zw!aszcza na limfocyty T pochodzące od chorych na atopowe zapalenie skóry.

7

Carbohydrate Chains and Their Binding Sites in Mistletoe Lectin I

Stoeva S., Maier T., Soler M., Voelter W.

Polish Journal of Chemistry

|

1999

|

vol. 73 nr 1

125-133

EN

The carbohydrate moieties, linked to mistletoe lectin 1 (ML-1) are characterized by enzymatic digestion of the individual A and B chains (MLA and MLB), HPLC separation of the (glyco)peptide digests and their sequence and mass spectrometric analysis. All carbohydrate chains are linked via Asn residues to the MLA protein molecule. A xylomannose-type oligosaccharide (1) structure (Man3Xyl1Fuc1GlcNac2) is attached to the Asn112 residue of the A chain. Three different glycosylation sites are identified for the B chain: oligosaccharide II (Man6GlcNac2) is found to be linked to Asn96 as well as Asn136 residues. In homologous mistletoe lectins, isolated from different harvest batches, oligosaccharide III (Man5GlcNac2) is attached to Asn136 instead of oligosaccharide II**.