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The biocompatibility of membranes for immunoisolation

Granicka L., Kawiak J., Weryński A.

Biocybernetics and Biomedical Engineering

2008

Vol. 28, no. 2

59-68

The assessment of biocompatibility of systems consisting of a host, permiselective membrane and a biological material, encapsulated within may be standardized for biological material immunoisolation purposes. The procedures for evaluation of the membrane non-toxicity against the biological material, the membrane physical and chemical stability post implantation and the biomaterial ability to perform with the host are presented.

Polypropylene surface modified hollow fibers for immunoisolation of cells

Granicka L. H., Chwojnowski A., Kawiak J.

Biocybernetics and Biomedical Engineering

2004

Vol. 24, no. 2

59-67

Membranes preventing the tissue overgrowth as well as toxic influence of the environment on cells encapsulated within them were elaborated. The permiselective polypropylene hollow fibers were modified using different methods of silanization, and the effect of silanization on the membrane transport properties as well as on the tissue overgrowth was assessed, in the light of their perspective application in encapsulation of the cells. The membrane's pressure silanization has been found to result in obtaining membranes allowing to decrease and/ or delimit the diffusive transport through the membrane of large solutes without a simultaneous transport change for small solutes. The applied different types of membrane's silanization allowed to avoid a massive tissue overgrowth during the implantation. The membranes have been found to comply with the requirements for membranes applied in immunoisolation.