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Synthesis, characterization and biological properties of intercalated kaolinite nanoclays: intercalation and biocompatibility

Yilmaz B., Irmak E. T., Turhan Y., Doğan S., Doğan M., Turhan O.

Advances in Materials Science

2019

Vol. 19, nr 1(59)

83--99

The aims of the present study were to synthesize the intercalated kaolinite samples with dimethylsulfoxide (DMSO), glutamic acid (GA), succinimide (SIM), cetylpyridiniumchloride (CPC), and hexadecyltrimethylammoniumchloride (HDTMA+); to characterize by X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy-attenuated total reflectance (FTIR-ATR), and to determine the hemocompatibility and the cytotoxic effects of the intercalated kaolinite nanoclays on human lymphocytes. It was found that the intercalation with DMSO did not cause any decrease in cell viability until its maximum concentration (500 μg/mL), however, the intercalation with SIM, CPC, and (HDTMA+) causd important decreases in lymphocyte viabilities. It was determined that no significant decrease was observed in protein content of the lymphocyte cells exposed to the kaolinite nanoclays except the ones intercalated with SIM. Furthermore, the pristine kaolinite nanoclays which were intercalated with DMSO, GA, and SIM exhibited high hemocompatibility and the nanoclays intercalated with CPC and (HDTMA+) were highly hemocompatibile for the amounts below 125 and 500 μg/mL, respectively. All the results of this work can serve for the human risk assesment of intercalated nanoclays.

Hemocompatibility of ultrafine systems on the basis of chitosan and its derivatives polymer-colloid complexes

Bazunova M. V., Kulish E. I., Tukhvatullin R. F., Sharafutdinova L. A., Shamratova V. G, Klimecka-Tatar D., Zaikov G. E.

Production Engineering Archives

2015

Vol. 6, No. 1

30--34

This article presents the results of the development process for the preparation of micro and nano-sized polymer-colloid complexes (РСС) on the basis of water-soluble natural polymer chitosan (СTZ) and the sodium salt of chitosan succinylamid (SСTZ) with silver halide sols in aqueous media. Results of research of СTZ, sodium salt of SСTZ solutions and PСС of CTZ and SСTZ with colloidal particles of silver iodide influence on structurally-functional properties of erythrocytes’ membranes on model of acidic hemolisis are presented in the article. Their influence on the nature of erythrocytes distribution by degree of their stability and on kinetic parameters (the beginning, intensity and completion of process of their destruction) under the influence of the damaging agent (HCl) is shown. The comparative analysis of results convinces that СTZ, SСTZ solutions and disperse systems on the basis of PСС of СTZ and SСTZ with colloidal particles of the silver iodide are capable of modulating variously matrix properties of erythrocytes of blood.

Haemocompatibility Of Non-Functionalized And Plasmachemical Functionalized Detonation Nanodiamond Particles

Mitura K., Jedrzejewska-Szczerska M., Ceynowa P., Dudek M., Cicha M., Kotela I., Mitura S.

Archives of Metallurgy and Materials

2015

Vol. 60, iss. 3

2183--2189

The purpose of this paper is to present the innovative design of microwave plasma system for modification of detonation nanodiamond particles (DNP) using a special rotating drum placed inside the reactor. Nanodiamond particles manufactured by detonation method reveal the biological activity depending on surface functionalization. Plasmachemical modification of detonation nanodiamond particles gives the possibility of controlling surface of nanodiamonds particles in biological tests. In this paper we would like to compare detonation nanodiamond (the grain sizes from 2 to 5 nm) with modified detonation nanodiamond in rotary reactor chamber, by microwave plasma activated chemical vapour deposition (MW PACVD) method in materials research (Raman and FT-IR spectroscopy) and in vitro examinations with full of human blood. The results indicate haemocompatibility of non-modified detonation nanodiamond and modified nanodiamond by MW PACVD method in rotary reactor chamber (modified ND-3) and the presence of haemolysis in commercial detonation nanodiamond.

Celem pracy jest przedstawienie innowacyjnego projektu systemu plazmy mikrofalowej z wykorzystaniem do modyfikacji detonacyjnych cząstek nanodiamontowych (DNP) przy użyciu specjalnego obrotowego bębna umieszczonego wewnątrz reaktora. Nanodiamontowe cząstki wytwarzane metodą detonacji wykazują aktywność biologiczną w zależności od funkcjonalizacji powierzchni. Plasmo-chemiczna modyfikacja detonacyjnych nanodiamontowych cząstek daje możliwość kontrolowania ich powierzchni w testach biologicznych. Autorzy w artykule porównali detonacyjny nanodiament (wielkość ziarna od 2 do 5 nm) ze zmodyfikowanym w obrotowej komorze reaktora, za pomocą procesu chemicznego osadzania wspomaganego plazmą mikrofalową (MW PACVD), detonacyjnym nanodiamentem. Wykorzystano badania materiałowe (Ramana i FT-IR spektroskopia) oraz badania in vitro na pełnej krwi ludzkiej. Badania wykazały hemozgodność niezmodyfikowanego detonacyjnego nanodiamentu i nanodiamentu zmodyfikowanego za pomocą metody MW PACVD w obrotowej komorze reaktora (zmodyfikowany ND-3) oraz obecność hemolizy w komercyjnym detonacyjnym nanodiamencie.