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Białka szoku cieplnego - wrażliwe biomarkery zagrożenia komórek stresem

Pedrycz A., Siermontowski P., Dudzińska M., Tomasiak M.

Polish Hyperbaric Research

2012

nr 2(39)

69-80

Białka szoku cieplnego zapobiegają działaniu szkodliwych czynników i regulują funkcjonowanie wielu procesów komórkowych. Tworzą niekowalencyjne połączenia a innymi strukturami zawierającymi polipeptydy, w sytuacji, gdy struktury te nie spełniają swoich biologicznych funkcji. Znajdują się w komórkach osób zdrowych. Ich stężenie spada wraz z wiekiem a wzrasta w stanach chorobowych. Celem obecnej pracy była analiza budowy i funkcji białek szoku cieplnego. Zwrócono uwagę na rolę jaką białka te odgrywają w procesie życia i śmierci komórek, w patogenezie wielu chorób, w tym nowotworowych, miażdżycy, nadciśnienia tętniczego. Przedstawiono kierunki badań nad możliwością wykorzystania białek szoku cieplnego w procesie terapii licznych chorób. Zauważono również, że białka te pełnią rolę biomarkerów stresu komórkowego wywołanego wieloma stresorami, w tym zanieczyszczeniem środowiska

Heat shock proteins prevent adverse effects induced by harmful conditions and regulate the functioning of numerous cellular processes. They produce non-convalescent connections with other structures containing polypeptides in situations when these structures do not fulfill their biological functions. They are present in the cells of healthy people and their concentration tends to decrease with age and increase at times of illness. The objective of the current work was to analyse the structuring and functions of heat shock proteins. The investigation looked at the role that such proteins play in the process of life and death of cells in the pathogenesis of many diseases, including cancerous diseases, sclerosis, and hypertension. This paper presents research directions examining the possibility of applying heat shock proteins in treating numerous diseases. Such proteins have also been observed to serve as biomarkers of cellular stress induced by a variety of stressors, including environmental pollution.

Temperature Fields Induced by Low Power Focused Ultrasound in Soft Tissues During Gene Therapy. Numerical Predictions and Experimental Results

Gambin B., Kujawska T., Kruglenko E., Mizera A., Nowicki A.

Archives of Acoustics

2009

Vol. 34, No. 4

445-459

The aim of this work is twofold. Firstly, to verify a theoretical model which is capable of predicting temperature fields appearing in soft tissues during their ultrasound treatment. Secondly, to analyze some aspects of the dynamics of Heat Shock Response induced by the heating process in the context of therapeutic treatment. The theoretical investigations and quantitive analysis of temperature increments at any field point versus time of heating process, depending on the heat source power, spatial distribution and duration as well as on the tissue thermal properties, has been carried out by Finite Element Method (FEM). The validation of the numerical model has been performed by comparison of the calculation results with the experimental data obtained by measuring in vitro of the 3D temperature increments induced in samples of the turkey and veal liver by the circular focused transducer with the diameter of 15 mm, focal length of 25 mm and resonance frequency of 2 MHz. Various ultrasonic regimes were considered. They were controlled by adjusting ultrasound power and exposure time. The heat shock proteins (HSP) and misfolded proteins (MFP) levels during the proposed cyclic sonification are presented.