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Application of instruments of nuclear physics to the calculation of theoretical dose distributions in various organs of the human body for beams used in hadrontherapy

Maliszewska W., Sękowski P., Skwira-Chalot I.

Nukleonika

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2016

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Vol. 61, No. 1

19--22

EN

The area of interests of nuclear physics are studies of reactions, wherein atomic nuclei of projectile collide with target nuclei. An amount of energy lost by projectile nucleus during its passing through the target is a major issue – it is important to know how charged particles interact with matter. It is possible to afford this knowledge by using theoretical programs that calculate energy loss applying the Bethe-Bloch equation. Hadrontherapy, which is a field of still growing interest, is based on the interactions of charged particles with matter. Therefore, there exists a need of creating a simple model that could be used to the calculation of dose distributions in biological matter. Two programs (SRIM, Xeloss), used to the calculation of energy loss by nuclear physicist, have been adapted to determine the dose distributions in analogues of human tissues. Results of the calculations with those programs for beams used in hadrontherapy (e.g. 1H, 12C) will be compared with experimental data available in references.

2

Monte Carlo calculated CT numbers for improved heavy ion treatment planning

Qamhiyeh S., Wysocka-Rabin A., Jäkel O.

Nukleonika

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2014

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Vol. 59, No. 1

15--23

EN

Better knowledge of CT number values and their uncertainties can be applied to improve heavy ion treatment planning. We developed a novel method to calculate CT numbers for a computed tomography (CT) scanner using the Monte Carlo (MC) code, BEAMnrc/EGSnrc. To generate the initial beam shape and spectra we conducted full simulations of an X-ray tube, filters and beam shapers for a Siemens Emotion CT. The simulation output files were analyzed to calculate projections of a phantom with inserts. A simple reconstruction algorithm (FBP using a Ram-Lak filter) was applied to calculate the pixel values, which represent an attenuation coefficient, normalized in such a way to give zero for water (Hounsfield unit (HU)). Measured and Monte Carlo calculated CT numbers were compared. The average deviation between measured and simulated CT numbers was 4 ± 4 HU and the standard deviation σ was 49 ± 4 HU. The simulation also correctly predicted the behaviour of H-materials compared to a Gammex tissue substitutes. We believe the developed approach represents a useful new tool for evaluating the effect of CT scanner and phantom parameters on CT number values.

3

Simulation of computed tomography (CT) images using a Monte Carlo approach

Wysocka-Rabin A. M., Qamhiyeh S., Jäkel O.

Nukleonika

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2011

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Vol. 56, No. 4

299-304

EN

Heavy ion treatment planning uses an empirical scanner-dependent calibration relation between computed tomography (CT) numbers and ion range. Any deviation in the values of CT numbers will cause a drift in the calibration curve of the CT scanner, which can reduce the accuracy of treatment beam delivery. To reduce uncertainty in the empirical estimation of CT numbers, we developed a simulation that takes into consideration the geometry, composition, and physical process that underlie their measurement. This approach uses Monte Carlo (MC) simulations, followed by a simple filtered back-projection reconstruction. The MC code used is BEAMnrc/EGSnrc. With the manufacturer’s permission, we simulated the components (X-ray tube, associated filters and beam shapers) of a Siemens Emotion CT. We then generated an initial beam shape and spectra, and performed further simulations using the phantom with substitutes. We analyzed the resulting phase space file to calculate projections, taking into account the energy response of the CT detectors. Then, we applied a simple reconstruction algorithm to the calculated projections in order to receive the CT image.