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Charakterystyka peptydów i białek zaangażowanych w utrzymywanie homeostazy jonów miedzi w układzie nerwowym człowieka

Komoszyńska A., Maćkiewicz Z.

Wiadomości Chemiczne

2007

[Z] 61, 7-8

547-565

Copper is an essential metal in living organisms. They all require copper as a catalytic cofactor for biological processes such as respiration, iron transport, oxidative stress protection and pigmentation. Nevertheless, exposure to the excess of copper can damage cells and organs. Copper ions and complexes can induce formation of reactive oxygen species, that can damage biomolecules including unsaturated lipids and DNA. In the past few years exciting advances have been made toward understanding how copper is transported within cells. Dysfunction of copper metabolism can lead to its excess or defi-ciency. Two examples of illness related to alterations in copper metabolism are Menkes and Wilson diseases. The understanding of copper homeostasis has become important in clinical medicine as the metal could be involved in the pathogenesis of some neurological disorders such as Alzheimer, Parkinson or prion diseases.