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2 Polish Journal of Chemistry

2 2005

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A Purification Strategy for Oligosaccharide Synthesis on Soluble Polymer Supports

Ojeda R., Martin-Lomas M.

Polish Journal of Chemistry

2005

Vol. 79 / nr 2

309-315

Removal of deficient sequences in the synthesis of oligosaccharides on soluble polymer supports can be efficiently achieved by selective esterification of the soluble supportbound incomplete glycosylation products with a conveniently functionalized insoluble resin.

A Facile Synthesis of the Fucosylated N-Linked Glycan Core and Its Application to Solid-Phase Synthesis of CD52 Glycopeptide

Shao N., Guo Z.

Polish Journal of Chemistry

2005

Vol. 79 / nr 2

297-307

An efficient synthesis of the fucosylated N-linked core hexasaccharide (23) and its asparagine conjugate (26), as well as their applications to the solid-phase synthesis of an extensively protected glycopeptide (1) of CD52 antigen containing the hexasaccharide, is described. The difficult beta-mannosidic and alfa-fucosidic linkages were achieved by the Crich and in situ anomerization protocols respectively, which offered excellent results. An especially acid-sensitive resin, 2-chlorotrityl resin, was used in the solid-phase synthesis, and the target glycopeptide 1 could be released from the resin by 10% HOAc without affecting the acid-labile protecting groups and fucosidic bond.