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Structure and activity studies of glycine receptor ligands : Part 4. N-[(7-arylalkyl, 7-aryloxyalkyl)-8-theophyllyl]-glycines

Drabczyńska A., Karolak-Wojciechowska J., Kieć-Kononowicz K.

Polish Journal of Chemistry

1999

vol. 73 nr 5

783-792

Preparation of N-[(7-arylalkyl, 7-aryloxyalkyl)-8-theophyllyl]-glycines by condensation of 8-bromo-theophylline with arylalkyl- and aryloxyalkylbromides and aminolysis with glycine is described. The structure of one of the obtained glycine derivatives was confirmed by X-ray analysis. A comparison of the glycine receptor binding model (molecule L-689,560) and the 3-D structure of that molecule indicates serious differences in molecule shape, explaining their inactivity.