Wyniki wyszukiwania - BazTech

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Furanokumaryny : naturalne związki organiczne o wielu właściwościach

Piechocka Justyna, Chwatko Grażyna, Owczarek Paulina

Wiadomości Chemiczne

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2023

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[Z] 77, 9-10

937--949

EN

Psoralen and angelicin are organic, natural chemical compounds, belonging to the furanocoumarin group, which are quite common in nature. Among others, these compounds are present in plants of the celery, rutaceae, mulberry and bean families, such as celery, carrot, lemon and fig. Interestingly, they exhibit a variety of biological activities, for instance insecticidal, anticonvulsant, anticancer, and antioxidant properties. For this reason, they are commonly used in different area of life. For example, psoralen is used in photochemotherapy as a photosensitizer in the treatment of psoriasis or acquired vitiligo (PUVA therapy). However, there is evidence that overexposure to psoralen and angelicin can also cause adverse effects. For these reasons, a number of analytical methods have been developed for their determination in environmental samples, while the vast majority of them are based on separation techniques. This paper discusses issues related to psoralen and angelicin and their analytics.

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Właściwości i zastosowanie pochodnych 2H-1-benzopiran-2-onu jako związków pochodzenia naturalnego

Czarna M., Kamińska I., Ortyl J.

Technical Issues

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2015

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nr 3

11--17

EN

This article is a detailed literature overview about properties and wide application of coumarin derivatives, whose representative is 2H-1-benzopyran-2-one. It turns out that this compounds can be found in many places all around the world. Huge part of them is already isolated and synthesized in laboratory conditions, however there are assumptions that many of them are not known at all and they might have an influence on science development. Considering to the structural variety of coumarin, its derivatives are characterized by different properties, what reflects numerous possibilities of their application and also attracts the interest of the world of science.

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Wpływ rodzaju i parametrów ekstrakcji na wydajność izolacji wybranych furanokumaryn z owoców gorysza wyniosłego (Peucedanum verticillare)

Waksmundzka-Hajnos M., Oniszczuk A., Podgórski R.

Camera Separatoria

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2012

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Vol. 4, No. 1

83--91

PL

Analiza materiału roślinnego jest ważnym zadaniem w poszukiwaniu roślin o działaniu farmakologicznym a także w standaryzacji leków roślinnych. Celem każdego procesu ekstrakcji jest szybka i skuteczna izolacja związków z matrycy przy użyciu minimalnej ilości rozpuszczalnika. Celem przedstawionej pracy był wybór optymalnych warunków do analizy materiału roślinnego oraz zbadanie wpływu metody ekstrakcji na wydajność izolacji niektórych furanokumaryn z owoców gorysza wyniosłego. Furanokumaryny mają istotne zastosowanie w lecznictwie. Są między innymi wykorzystywane w terapii bielactwa i łuszczycy oraz leczeniu skórnego T-komórkowego chłoniaka z erytmodermią. Zastosowano następujące metody ekstrakcyjne: wyczerpująca ekstrakcja w aparacie Soxhleta, ekstrakcja wspomagana ultradźwiękami w temperaturze 20 i 60◦C oraz ekstrakcja wspomagana mikrofalami w układzie otwartym i zamkniętym. Analiza została przeprowadzona metodą wysokosprawnej chromatografii cieczowej z detektorem UV/VIS. Wyniki wskazują, że najwyższą wydajność imperatoryny uzyskano w wyniku ekstrakcji ultradźwiękowej 60◦C, natomiast metodą najskuteczniejszą do izolacji umbeliferonu okazała się ekstrakcja mikrofalowa w układzie zamkniętym.

EN

Analysis of plant material is an important task in chemotaxonomical investigations, particularly, in search of plants with pharmacological activity or in standardisation of plant drugs. The goal of every extraction process is rapid and effective isolation of compounds from a matrix by use of minimum amount of solvent. The aim of this paper was the choice of optimal condi-tions for the analysis of plant material and effect of extraction method on the yield of some furanocoumarins from Peucedanum verticillare fruits. Furanocoumarins have important uses in human medicine and exhibit toxicity against a wide range of organisms. This group of com-pounds reveal pharmacological activity. They are important drugs in vitiligo and psoriaris therapy and are also used in therapy erythrodermic variants of cutaneous T-cell lymphoma and chronic graft-versus-host disease. The following extraction methods were used in our experiments: exhaustive extraction in Soxh-let apparatus, ultrasound- assisted solvent extraction (USAE) at 20 and 60◦C as well as micro-wave-assisted solvent extraction in open and closed system (MASE). Target compounds analysis was performed by high performance liquid chromatography with UV/VIS detector. The results indicated that, the highest yield of imperatorin can be obtained by ultrasonification at 60◦C, while microwave-assisted solvent extraction in closed system is very efficient in the extraction of umbelliferone.

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Psolareny : wtórne metabolity roślin baldaszkowatych

Tomaszkiewicz-Potępa A., Burgiel Z.J., Vogt O.Z.

Wiadomości Chemiczne

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2007

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[Z] 61, 9-10

759-784

EN

Plant secondary metabolites have been used for thousands of years as pharmaceuticals and dyes or as natural pesticides. Furanocoumarins are one of the more important secondary metabolites of many plants. Many sorts of furanocoumarins are known. Psolaren and its derivatives belong to them. Linear furanocoumarins have been isolated from wild and garden plants (Umbelliferae, Apiacae, Leguminosae). The increase of psolarens content (even dozens as much) in plants may be caused both by pathogenic bacterium or virus infection and by insects attack. This effect is used to obtain these compounds. The psolaren and its derivatives can also be prepared by the synthetic way. It is realized in the consequence of two-reaction pathway: (1) by the construction of the carbon framework from three condensed rings (starting from suitable derivatives of the resorcin) and (2) by the chemical modification of substituents. The combination of these methods allows us to synthesize the majority of naturally occurring psolarens and its derivatives characterized by considerable biological activity. Psolaren and its derivatives (linear furanocoumarins) are used in dermatology for treatment of skin diseases such as vitiligo and psoriasis. They have also been used as probes of nucleic acid structure and function. Psolaren demonstrates high activity towards UV. Its therapeutic activity and biocidality is caused by reactions that takes place in these conditions. Psolarens, in the presence of UV, interact with DNA inhibiting its replication.